| TG containing stearic acid, synthesized from coconut oil, exhibit lipidemic effects in rats similar to those of cocoa butter. | |
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MedLine Citation:
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PMID: 14584598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipase-catalyzed interesterification was used to prepare structured TG from coconut oil TG by partially replacing some of the atherogenic saturated FA with stearic acid, which is known to have a neutral effect on lipid levels in the body. The level of stearic acid was increased from 4% in the native coconut oil to 40% in the structured lipids, with most of the stearic acid being incorporated into the sn-1 and sn-3 positions of TG. When structured lipids were fed to rats at a 10% level for a period of 60 d, a 15% decrease in total cholesterol and a 23% decrease in LDL cholesterol levels in the serum were observed when compared to those fed coconut oil. Similarly, the total and free cholesterol levels in the livers of the rats fed structured lipids were lowered by 31 and 36%, respectively, when compared to those fed coconut oil. The TG levels in the serum and in the liver showed decreases of 14 and 30%, respectively, in animals fed structured lipids. Rats fed cocoa butter and structured lipids having a similar amount of stearic acid had similar lipid levels in the serum and liver. These studies indicated that the atherogenic potential of coconut oil lipids can be reduced significantly by enriching them with stearic acid. This also changed the physical properties of coconut oil closer to those of cocoa butter as determined by DSC. |
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Authors:
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Reena Rao; Belur R Lokesh |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lipids Volume: 38 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-10-30 Completed Date: 2004-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: United States |
Other Details:
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Languages: eng Pagination: 913-8 Citation Subset: IM |
Affiliation:
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Department of Lipid Science and Traditional Foods, Central Food Technological Research Institute, Mysore-570 013, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Dietary Fats / chemical synthesis, pharmacology* Feces / chemistry Lipids / blood Liver / drug effects, metabolism Male Organ Size / drug effects Plant Oils / chemistry* Rats Rats, Wistar Stearic Acids / analysis* Temperature Triglycerides / chemical synthesis*, chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Lipids; 0/Plant Oils; 0/Stearic Acids; 0/Triglycerides; 57-11-4/stearic acid; 8001-31-8/coconut oil; 8002-31-1/cocoa butter |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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