| TEL(ETV6)-AML1(RUNX1) Initiates Self-renewing Fetal Pro-B Cells in Association with a Transcriptional Program Shared with Embryonic Stem Cells in Mice. | |
| | |
MedLine Citation:
|
PMID: 23135987 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The initial steps involved in the pathogenesis of acute leukemia are poorly understood. The TEL-AML1 fusion gene usually arises before birth, producing a persistent and covert preleukemic clone that may convert to precursor B cell leukemia following the accumulation of secondary genetic "hits". Here we show that TEL-AML1 can induce persistent self-renewing pro-B cells in mice. TEL-AML1+ cells nevertheless differentiate terminally in the long term, providing a "window" period that may allow secondary genetic "hits" to accumulate and lead to leukemia. TEL-AML1-mediated self-renewal is associated with a transcriptional program shared with embryonic stem cells (ESCs), within which Mybl2, Tgif2, Pim2 and Hmgb3 are critical and sufficient components to establish self-renewing pro-B cells. We further show that TEL-AML1 increases the number of leukemia-initiating cells that are generated in collaboration with additional genetic "hits", thus providing an overall basis for the development of novel therapeutic and preventive measures targeting the TEL-AML1-associated transcriptional program. |
| | |
Authors:
|
Shinobu Tsuzuki; Masao Seto |
Related Documents
:
|
15959627 - The molecular mechanism of actinomycin d in preventing neointimal formation in rat caro... 23687087 - Nrasg12d/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell fun... 23568777 - Dynamic changes in fetal leydig cell populations influence adult leydig cell population... 18673267 - Stem cell implantation for myocardial disorders. 15959627 - The molecular mechanism of actinomycin d in preventing neointimal formation in rat caro... 21195737 - Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by hum... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-8 |
Journal Detail:
|
Title: Stem cells (Dayton, Ohio) Volume: - ISSN: 1549-4918 ISO Abbreviation: Stem Cells Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9304532 Medline TA: Stem Cells Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 AlphaMed Press. |
Affiliation:
|
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan. stsuzuki@aichi-cc.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Investigation of the genetic diversity among native Turkish sheep breeds using mtDNA polymorphisms.
Next Document: Risk factors and outcomes for primary, revision, and modified Lothrop (Draf III) frontal sinus surge...