| TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden. | |
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MedLine Citation:
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PMID: 17245407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D. |
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Authors:
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Sofia Mayans; Kurt Lackovic; Petter Lindgren; Karin Ruikka; Asa Agren; Mats Eliasson; Dan Holmberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-24 |
Journal Detail:
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Title: European journal of human genetics : EJHG Volume: 15 ISSN: 1018-4813 ISO Abbreviation: Eur. J. Hum. Genet. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-22 Completed Date: 2007-04-18 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 9302235 Medline TA: Eur J Hum Genet Country: England |
Other Details:
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Languages: eng Pagination: 342-6 Citation Subset: IM |
Affiliation:
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Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Diabetes Mellitus, Type 2 / genetics* Family Female Genetic Predisposition to Disease* Humans Male Polymorphism, Single Nucleotide* Sweden TCF Transcription Factors / genetics* |
| Chemical | |
Reg. No./Substance:
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0/TCF Transcription Factors; 0/Tcf7L2 transcription factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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