Document Detail


TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden.
MedLine Citation:
PMID:  17245407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D.
Authors:
Sofia Mayans; Kurt Lackovic; Petter Lindgren; Karin Ruikka; Asa Agren; Mats Eliasson; Dan Holmberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-24
Journal Detail:
Title:  European journal of human genetics : EJHG     Volume:  15     ISSN:  1018-4813     ISO Abbreviation:  Eur. J. Hum. Genet.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-04-18     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  9302235     Medline TA:  Eur J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
Affiliation:
Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Diabetes Mellitus, Type 2 / genetics*
Family
Female
Genetic Predisposition to Disease*
Humans
Male
Polymorphism, Single Nucleotide*
Sweden
TCF Transcription Factors / genetics*
Chemical
Reg. No./Substance:
0/TCF Transcription Factors; 0/Tcf7L2 transcription factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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