Document Detail


TBX2 expression is regulated by PAX3 in the melanocyte lineage.
MedLine Citation:
PMID:  23020925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T-box 2 (TBX2), a key developmental regulator of cell identity and an antisenescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is involved in the survival of melanoma cells and is overexpressed in some melanoma specimens. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution and may provide opportunities for prosenescence therapeutic intervention aimed at disrupting the ability of PAX3 to regulate TBX2.
Authors:
Fang Liu; Juxiang Cao; Jinghu Lv; Liang Dong; Eric Pier; George X Xu; Rui-an Wang; Zhixiang Xu; Colin Goding; Rutao Cui
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-21
Journal Detail:
Title:  Pigment cell & melanoma research     Volume:  26     ISSN:  1755-148X     ISO Abbreviation:  Pigment Cell Melanoma Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-20     Completed Date:  2013-06-13     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101318927     Medline TA:  Pigment Cell Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-77     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage* / genetics
Cell Proliferation
Cell Survival / genetics
Chromatin Immunoprecipitation
Gene Expression Regulation*
Gene Expression Regulation, Neoplastic
Humans
Melanocytes / metabolism*,  pathology
Melanoma / genetics,  pathology
Mice
Oligonucleotide Array Sequence Analysis
Paired Box Transcription Factors / metabolism*
Promoter Regions, Genetic / genetics
Protein Binding / genetics
T-Box Domain Proteins / genetics*,  metabolism
Up-Regulation / genetics
Grant Support
ID/Acronym/Agency:
7R01CA137098/CA/NCI NIH HHS; R01 CA137098/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/PAX3 protein, human; 0/Paired Box Transcription Factors; 0/T-Box Domain Protein 2; 0/T-Box Domain Proteins; 138016-91-8/Pax3 protein, mouse
Comments/Corrections

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