| TB and MDR/XDR-TB in the EU and EEA countries: managed or mismanaged? | |
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MedLine Citation:
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PMID: 22323578 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In spite of the growing awareness of emerging drug-resistant M. tuberculosis, the extent of inappropriate tuberculosis (TB) case-management may be underestimated, even in Europe.We evaluated TB case-management in the EU/EEA countries, with special focus on multi- and extensively drug-resistant (MDR/XDR) TB, using a purposely developed, standardised survey tool.National reference centres in five countries representing different geographical, socio-economical and epidemiological patterns of TB in Europe were surveyed. Forty consecutive, original clinical TB case-records (30 MDR-/XDR-TB) in each of the 5 countries were reviewed. The findings were recorded and, through the survey tool, compared with previously agreed and identified international standards.Deviations from international standards of TB care were observed in the areas of surveillance (no information available on patient outcomes), infection control (lack of respiratory isolation rooms/procedures, and negative-pressure ventilation rooms), clinical management of TB, MDR-TB and HIV co-infection (inadequate bacteriological diagnosis, regimen selection and treatment duration), laboratory support and diagnostic/treatment algorithms.Gaps between present international standards of care and the management of MDR/XDR-TB patients were identified. Training, increased awareness, promotion of standards, and allocation of appropriate resources are necessary to ensure appropriate care and management as well as to prevent further emergence of drug-resistance. |
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Authors:
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G B Migliori; G Sotgiu; L D'Ambrosio; R Centis; C Lange; G Bothamley; D M Cirillo; S De Lorenzo; G Guenther; K Kliiman; R Muetterlein; V Spinu; M Villar; J P Zellweger; A Sandgren; E Huitric; D Manissero |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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WHO Collaborating Centre, Via Roncaccio 16, Tradate, Varese 21049Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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