| TASK-3 channel deletion in mice recapitulates low-renin essential hypertension. | |
| | |
MedLine Citation:
|
PMID: 22493079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Idiopathic primary hyperaldosteronism (IHA) and low-renin essential hypertension (LREH) are common forms of hypertension, characterized by an elevated aldosterone-renin ratio and hypersensitivity to angiotensin II. They are suggested to be 2 states within a disease spectrum that progresses from LREH to IHA as the control of aldosterone production by the renin-angiotensin system is weakened. The mechanism(s) that drives this progression remains unknown. Deletion of Twik-related acid-sensitive K(+) channels (TASK) subunits, TASK-1 and TASK-3, in mice (T1T3KO) produces a model of human IHA. Here, we determine the effect of deleting only TASK-3 (T3KO) on the control of aldosterone production and blood pressure. We find that T3KO mice recapitulate key characteristics of human LREH, salt-sensitive hypertension, mild overproduction of aldosterone, decreased plasma-renin concentration with elevated aldosterone:renin ratio, hypersensitivity to endogenous and exogenous angiotensin II, and failure to suppress aldosterone production with dietary sodium loading. The relative differences in levels of aldosterone output and aldosterone:renin ratio and in autonomy of aldosterone production between T1T3KO and T3KO mice are reminiscent of differences in human hypertensive patients with LREH and IHA. Our studies establish a model of LREH and suggest that loss of TASK channel activity may be one mechanism that advances the syndrome of low renin hypertension. |
| | |
Authors:
|
Nick A Guagliardo; Junlan Yao; Changlong Hu; Elaine M Schertz; David A Tyson; Robert M Carey; Douglas A Bayliss; Paula Q Barrett |
Related Documents
:
|
2292369 - Heritability of blood pressure in 7- to 12-year-old chinese twins, with special referen... 15579059 - Pathophysiology and treatment of obesity hypertension. 18283269 - Children and adolescents with obesity and the metabolic syndrome have high circulating ... 3618749 - Family resemblance for anthropometric and blood pressure measurements in black caribs a... 15662209 - Effect of resistance training on resting blood pressure: a meta-analysis of randomized ... 15253209 - Intraabdominal pressure after full abdominoplasty in obese multiparous patients. 2580449 - Dextran and capillary filtration coefficient in cat hindlimb. 1138269 - Evaluation of a videodensitometric method for monitoring the left ventricular contracti... 19030139 - Presence of metabolic syndrome in football linemen. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2012-04-09 |
Journal Detail:
|
Title: Hypertension Volume: 59 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-20 Completed Date: 2012-06-14 Revised Date: 2013-05-03 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
|
Languages: eng Pagination: 999-1005 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
metabolism Angiotensin II / pharmacology Animals Disease Models, Animal Gene Expression Regulation Humans Hyperaldosteronism / genetics*, physiopathology Hypertension / genetics*, physiopathology* Mice Mice, Inbred C57BL Mice, Knockout Potassium Channels / genetics*, metabolism Random Allocation Real-Time Polymerase Chain Reaction Renin-Angiotensin System / genetics*, physiology Sensitivity and Specificity Sequence Deletion Sodium / metabolism, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
HL-036977/HL/NHLBI NIH HHS; HL-089717/HL/NHLBI NIH HHS; NS-33583/NS/NINDS NIH HHS; R01 HL036977/HL/NHLBI NIH HHS; R01 HL089717/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Potassium Channels; 0/TASK3 protein, mouse; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 7440-23-5/Sodium |
| Comments/Corrections | |
Erratum In:
|
Hypertension. 2012 Jun;59(6):e59 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of High Glycemic Index and Glycemic Load Diets on Blood Pressure During Adolescence.
Next Document: Stromal-derived IL-6 alters the balance of myeloerythroid progenitors during Toxoplasma gondii infec...