Document Detail


Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.
MedLine Citation:
PMID:  23389994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Our study provides new mechanistic insights into the regulation of glycolysis in HCC cells and reveals TARDBP as a potential therapeutic target for HCC.
Authors:
Yun-Yong Park; Sang-Bae Kim; Hee Dong Han; Bo Hwa Sohn; Ji Hoon Kim; Jiyong Liang; Yiling Lu; Cristian Rodriguez-Aguayo; Gabriel Lopez-Berestein; Gordon B Mills; Anil K Sood; Ju-Seog Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-05-15
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Platelets / enzymology
Carcinoma, Hepatocellular / metabolism,  physiopathology*
Cell Line, Tumor
DNA-Binding Proteins / physiology*
Female
Glycolysis / drug effects,  genetics
Humans
Liver Neoplasms / metabolism,  physiopathology*
Mice
MicroRNAs / antagonists & inhibitors,  physiology*
Phosphofructokinase-1, Type C / genetics*
Grant Support
ID/Acronym/Agency:
5P01CA099031-07/CA/NCI NIH HHS; 5U54 CA112970-08/CA/NCI NIH HHS; CA016672/CA/NCI NIH HHS; P30 CA016672/CA/NCI NIH HHS; P30 CA016672/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/MIRN520 microRNA, human; 0/MicroRNAs; 0/protein TDP-43; EC 2.7.1.-/Phosphofructokinase-1, Type C
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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