Document Detail

TAFI activity and antigen plasma levels are not increased in acute coronary artery disease patients admitted to a coronary care unit.
MedLine Citation:
PMID:  16318869     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Hypofibrinolysis, at least in part due to high levels of plasminogen activator inhibitor-1 (PAI-1), has been reported to occur frequently in patients with coronary artery disease (CAD). A recently described carboxypeptidase, thrombin-activatable fibrinolysis inhibitor (TAFI), is involved in the regulation of the balance between coagulation and fibrinolysis. High TAFI plasma levels may therefore contribute to a hypofibrinolytic state and to an increased risk for thrombotic disorders. There are contradictory results regarding TAFI levels in CAD patients, possibly because the characteristics of patients investigated and the time of blood sampling were different among different studies. MATERIALS AND METHODS: Fibrinolytic inhibitors (TAFI activity, TAFI antigen and PAI-1 activity plasma levels) were measured in 44 consecutive patients admitted to the Coronary Care Unit of the University of Florence and in a group of 44 healthy controls, matched for age and sex, to detect a possible association of their levels with acute CAD. RESULTS: No differences were found in TAFI levels, either activity or antigen, between patients and controls. PAI-1 activity was significant different between patients and controls (p=0.0001). The frequencies of TAFI activity and antigen over cut-off levels were similar in patients and controls. Instead, higher PAI-1 levels were more frequent (p=0.04) in patients respect to controls. The univariate analysis confirmed the association of increased PAI-1 levels with acute CAD [OR=3.3; p=0.04]. Among the patients, TAFI and PAI-1 levels were not different according to clinical presentation of symptoms or indication to immediate percutaneous revascularization. CONCLUSION: Our study suggests that in acute phase of CAD no increased levels of TAFI are detectable in plasma.
Anna Paola Cellai; Emilia Antonucci; Agatina Alessandrello Liotta; Sandra Fedi; Rossella Marcucci; Michela Falciani; Cristina Giglioli; Rosanna Abbate; Domenico Prisco
Related Documents :
19909929 - Assessment of coronary plaque progression in coronary computed tomography angiography u...
19763659 - Comparative study of clinical characteristics between chinese han and german caucasian ...
12632029 - Fibrinolytic response to venous occlusion is decreased in patients after kawasaki disease.
8901759 - Sudden cardiac death in cardiac transplant recipients.
2955019 - Multilesion coronary angioplasty: clinical and angiographic follow-up.
16318869 - Tafi activity and antigen plasma levels are not increased in acute coronary artery dise...
4076199 - Effects of intravenous diltiazem administration in patients with inducible tachycardia.
18209149 - Reduced mortality at a community hospital trauma center: the impact of changing trauma ...
21661349 - Thorough clinical evaluation of skin, as well as oral, genital and anal mucosa is benef...
Publication Detail:
Type:  Journal Article     Date:  2005-11-28
Journal Detail:
Title:  Thrombosis research     Volume:  118     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-04     Completed Date:  2007-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
Department of Medical and Surgical Critical Care, Thrombosis Centre, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Aged, 80 and over
Carboxypeptidase U / blood*
Coronary Angiography / methods
Coronary Artery Disease / blood*,  diagnosis,  therapy
Coronary Care Units*
Enzyme Activation
Middle Aged
Plasminogen Activator Inhibitor 1 / blood*
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; EC U

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effects of direct current cardioversion for persistent atrial fibrillation on indices of endothe...
Next Document:  Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors.