| The T3(b) gene promoter directs intestinal epithelial cell-specific expression in transgenic mice. | |
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MedLine Citation:
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PMID: 10601664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although a few promoters that direct intestinal epithelial cell-specific expression in transgenic animals have been reported, they are not necessarily appropriate for transgenic studies in terms of activity and tissue specificity. Here, we examined the tissue specificity of transgene expression directed by the 2.8-kb promoter region of the T3(b) gene, which encodes one of the non-classical major histocompatibility complex class I molecules. The transgene was expressed exclusively in the epithelial cells of the small and large intestines at high levels. The results indicate that the T3(b) promoter is useful for directing transgene expression specifically in intestinal epithelial cells. |
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Authors:
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H Aihara; N Hiwatashi; S Kumagai; Y Obata; T Shimosegawa; T Toyota; J Miyazaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 463 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-02-03 Completed Date: 2000-02-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 185-8 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Physiological Chemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Northern Blotting, Southern Gene Expression Regulation* Immunohistochemistry Inflammatory Bowel Diseases / metabolism Interleukin-12 / biosynthesis, genetics Intestinal Mucosa / metabolism* Intestine, Large / metabolism Intestine, Small / metabolism Mice Mice, Transgenic Peptide Fragments / biosynthesis, genetics Promoter Regions, Genetic* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 187348-17-0/Interleukin-12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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