Document Detail

T2-weighted and T2 relaxometry images in patients with medial temporal lobe epilepsy.
MedLine Citation:
PMID:  16808828     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Quantification of increased T2-weighted MRI signal that is associated with hippocampal sclerosis (HS) can be performed through (1) mean of hippocampal signal in single-echo T2 MRI and (2) hippocampal T2 relaxometry. It is not clear whether these two techniques are equivalent. In this study, we compare the hippocampal signal, detected by single-echo T2 quantification and by T2 relaxometry, in patients with medial temporal lobe epilepsy (MTLE). METHODS: We studied magnetic resonance images from 50 MTLE patients and 15 healthy subjects. We compared the quantification of a T2 signal from single echo images to T2 relaxometry, both obtained from a manually traced region of interest (ROI) in coronal slices involving the whole hippocampus. Repeated measures ANOVA was used to evaluate the differences in the distribution of the Z-scores from single-echo T2 quantification and T2 relaxometry within subjects. RESULTS: We observed a significant difference between the measurements obtained from single-echo T2 quantification and T2 relaxometry (P < .001). Measurements from head, body, and tail of the hippocampus were different (P=.04), with a significant interaction between anatomic location and type of measurement used (P= .008). Post hoc paired comparisons revealed that T2 relaxometry yielded greater Z-scores for the body (P= .002) and tail (P < .0001). CONCLUSIONS: For each subject with MTLE, T2 relaxometry was able to detect a higher signal in the body and tail of the hippocampus compared to single-echo T2. This is a possible indicator that T2 relaxometry is more sensitive in detecting T2 abnormalities within the body and tail of the hippocampus in patients with MTLE.
Ana Carolina Coan; Leonardo Bonilha; Paul S Morgan; Fernando Cendes; Li Min Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  16     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  260-5     Citation Subset:  IM    
Neuroimaging Laboratory, Department of Neurology, State University of Campinas, 13083-970 Campinas, SP, Brazil.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Epilepsy, Temporal Lobe / pathology*
Hippocampus / pathology*
Magnetic Resonance Imaging / methods*

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