Document Detail

T2*-weighted and arterial spin labeling MRI of calf muscles in healthy volunteers and patients with chronic exertional compartment syndrome: preliminary experience.
MedLine Citation:
PMID:  19770303     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of our study was to assess temporal changes with exercise in T2* and arterial spin labeling signals in patients with chronic exertional compartment syndrome of the anterior compartment of the lower leg and in control subjects using T2* mapping and arterial spin labeling MRI. SUBJECTS AND METHODS: This prospective study was approved by the institutional research ethics board. Ten control subjects (five women and five men; mean age, 29.0 years) and nine patients with chronic exertional compartment syndrome (three women and six men; mean age, 33.7 years) gave informed written consent and underwent MRI of the calf muscles using an axial T2*-weighted multiecho gradient-recalled echo and a flow-sensitive alternating inversion recovery sequence with echo-planar imaging readouts before (baseline) and 3, 6, 9, 12, and 15 minutes after exercise. T2* and arterial spin labeling signal changes (DeltaT2* and DeltaASL, respectively) over time were calculated relative to the baseline examination. DeltaT2* and DeltaASL between patients and control subjects were compared using the Student's t test. RESULTS: In both patients and control subjects, DeltaT2* and DeltaASL showed a peak at 3 minutes after exercise, followed by a decrease over time. The maximum DeltaT2* was 26% and 29% for patients and control subjects, respectively. The maximum DeltaASL was 183% and 224% for patients and control subjects, respectively. After 15 minutes, arterial spin labeling signal returned to baseline; however, T2* remained elevated (8% in patients; 10% in control subjects). No statistically significant differences between patients and control subjects in postexercise DeltaT2* and DeltaASL were found (p = 0.21-0.98). CONCLUSION: After calf muscle exercise, no statistically significant differences in T2* relaxation times or arterial spin labeling signal, indicative of differences in muscle oxygenation and perfusion status, were found between patients with chronic exertional compartment syndrome and control subjects.
Gustav Andreisek; Lawrence M White; Marshall S Sussman; Deanna L Langer; Chirag Patel; Jason Wen-Shyang Su; Masoom A Haider; Jeff A Stainsby
Related Documents :
25245143 - Non-invasive assessment of animal exercise stress: real-time pcr of glut4, cox2, sod1 a...
1086743 - Determination of improved myocardial perfusion after aortocoronary bypass surgery by ex...
14742733 - The effect of tropomyosin on force and elementary steps of the cross-bridge cycle in re...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  193     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-22     Completed Date:  2009-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  W327-33     Citation Subset:  AIM; IM    
Division of Musculoskeletal Imaging, Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, University of Toronto, Toronto, ON, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anterior Compartment Syndrome / diagnosis*
Chronic Disease
Cumulative Trauma Disorders / diagnosis*
Leg / pathology
Middle Aged
Muscle, Skeletal / pathology*
Physical Exertion*
Pilot Projects
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Spin Labels
Young Adult
Reg. No./Substance:
0/Spin Labels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction...
Next Document:  Anterior ankle impingement and talar bony outgrowths: osteophyte or enthesophyte? Paleopathologic an...