| T2 relaxation rate as an index of pituitary iron overload in patients with beta-thalassemia major. | |
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MedLine Citation:
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PMID: 11090376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In transfusion-dependent ss-thalassemia major, increased iron deposition in the pituitary gland has a cytotoxic effect, leading mainly to hypogonadotropic hypogonadism. Early detection and quantification of iron in the pituitary gland are of particular importance for successful treatment. The purpose of this study was to evaluate the T2 relaxation rate (1/T2) as a marker of pituitary siderosis. SUBJECTS AND METHODS: In 29 patients with ss-thalassemia major and 40 controls, we assessed the 1/T2 of the pituitary gland in a 1.5-T MR unit, using a multiecho spin-echo sequence. In all patients, an extensive endocrine evaluation was performed, including measurements of spontaneous and stimulated levels of gonadotropins, thyroid hormones, growth hormone, insulinlike growth factor, and adrenal hormones. RESULTS: A positive correlation was found between the 1/T2 and the serum ferritin level (r = 0.73, p < 0.001). The 1/T2 was higher in patients (mean, 0.020 msec(-1); SD, 0.006) compared with that of controls (mean, 0.011 msec(-1); SD, 0.001; p < 0.001). The 1/T2 was higher in patients with hypogonadotropic hypogonadism (mean, 0.024 msec(-1); SD, 0.006) in comparison with that of patients without any pituitary dysfunction (mean, 0.017 msec(-1); SD, 0.004; p < 0.05). CONCLUSION: The T2 relaxation rate could be used as an index of pituitary iron overload, and it might be of value to monitor treatment with deferoxamine in patients with ss-thalassemia major. |
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Authors:
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M I Argyropoulou; Z Metafratzi; D N Kiortsis; S Bitsis; A Tsatsoulis; S Efremidis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 175 ISSN: 0361-803X ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-03 Completed Date: 2001-01-03 Revised Date: 2008-02-15 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1567-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, School of Medicine, University of Ioannina, 45110, Ioannina, Greece. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Chelating Agents / adverse effects, therapeutic use Deferoxamine / adverse effects, therapeutic use Female Ferritins / blood Humans Magnetic Resonance Imaging* Male Pituitary Gland / pathology* Siderosis / diagnosis*, etiology beta-Thalassemia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 70-51-9/Deferoxamine; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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