Document Detail


T2 relaxation rate as an index of pituitary iron overload in patients with beta-thalassemia major.
MedLine Citation:
PMID:  11090376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In transfusion-dependent ss-thalassemia major, increased iron deposition in the pituitary gland has a cytotoxic effect, leading mainly to hypogonadotropic hypogonadism. Early detection and quantification of iron in the pituitary gland are of particular importance for successful treatment. The purpose of this study was to evaluate the T2 relaxation rate (1/T2) as a marker of pituitary siderosis. SUBJECTS AND METHODS: In 29 patients with ss-thalassemia major and 40 controls, we assessed the 1/T2 of the pituitary gland in a 1.5-T MR unit, using a multiecho spin-echo sequence. In all patients, an extensive endocrine evaluation was performed, including measurements of spontaneous and stimulated levels of gonadotropins, thyroid hormones, growth hormone, insulinlike growth factor, and adrenal hormones. RESULTS: A positive correlation was found between the 1/T2 and the serum ferritin level (r = 0.73, p < 0.001). The 1/T2 was higher in patients (mean, 0.020 msec(-1); SD, 0.006) compared with that of controls (mean, 0.011 msec(-1); SD, 0.001; p < 0.001). The 1/T2 was higher in patients with hypogonadotropic hypogonadism (mean, 0.024 msec(-1); SD, 0.006) in comparison with that of patients without any pituitary dysfunction (mean, 0.017 msec(-1); SD, 0.004; p < 0.05). CONCLUSION: The T2 relaxation rate could be used as an index of pituitary iron overload, and it might be of value to monitor treatment with deferoxamine in patients with ss-thalassemia major.
Authors:
M I Argyropoulou; Z Metafratzi; D N Kiortsis; S Bitsis; A Tsatsoulis; S Efremidis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  175     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-03     Completed Date:  2001-01-03     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1567-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, School of Medicine, University of Ioannina, 45110, Ioannina, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Chelating Agents / adverse effects,  therapeutic use
Deferoxamine / adverse effects,  therapeutic use
Female
Ferritins / blood
Humans
Magnetic Resonance Imaging*
Male
Pituitary Gland / pathology*
Siderosis / diagnosis*,  etiology
beta-Thalassemia / drug therapy*
Chemical
Reg. No./Substance:
0/Chelating Agents; 70-51-9/Deferoxamine; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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