| T(1ρ) and T(2) quantitative magnetic resonance imaging analysis of cartilage regeneration following microfracture and mosaicplasty cartilage resurfacing procedures. | |
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MedLine Citation:
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PMID: 20882622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine T(1ρ) (T1rho) and T(2) quantitative magnetic resonance imaging (MRI) in evaluating cartilage regeneration following microfracture (MFx) and mosaicplasty (MOS) cartilage resurfacing procedures. MATERIALS AND METHODS: Eighteen patients underwent MFx and eight patients underwent MOS to treat symptomatic focal cartilage defects. Quantitative T(1ρ) and T(2) maps were acquired at 3-6 months and 1 year after surgery. The area of resurfacing was identified, and T(1ρ) and T(2) values for the regenerated tissue (RT) and normal cartilage (NC) were acquired. RT/NC ratios were calculated to standardize absolute T(1ρ) and T(2) values. Data were prospective, cross-sectional, and nonrandomized. RESULTS: T(1ρ) and T(2) showed good reanalysis reproducibility for RT and NC. Significant differences between RT and NC were present following MFx at 3-6 months for T(1ρ) and T(2) values as well as following MOS at 3-6 months and 1 year for T(1ρ) values. Following MFx, the T(2) RT/NC ratio was significantly different between 3-6 months and 1 year (P = 0.02), while the T(1ρ) RT/NC ratio approached significance (P = 0.07). Following MOS, the T(1ρ) and T(2) RT/NC ratios were not significantly different between the two timepoints. CONCLUSION: T(1ρ) and T(2) MRI are complementary and reproducible methods for quantitatively and noninvasively monitoring regeneration of RT following MFx and MOS. |
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Authors:
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Daniel J Holtzman; Alexander A Theologis; Julio Carballido-Gamio; Sharmila Majumdar; Xiaojuan Li; C Benjamin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-02-02 Revised Date: 2012-04-06 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 914-23 Citation Subset: IM |
Affiliation:
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School of Medicine, University of California, San Francisco (UCSF), San Francisco, California 94158, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Automation Cartilage / pathology Cartilage, Articular / injuries, pathology* Cross-Sectional Studies Female Fracture Healing Humans Imaging, Three-Dimensional Knee Joint / pathology* Magnetic Resonance Imaging / methods* Male Prospective Studies Regeneration* |
| Grant Support | |
ID/Acronym/Agency:
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K25 AR053633/AR/NIAMS NIH HHS; R01 AR046905-10/AR/NIAMS NIH HHS; R01 AR046905-12/AR/NIAMS NIH HHS; R01 AR46905/AR/NIAMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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