Document Detail


T(1ρ) and T(2) quantitative magnetic resonance imaging analysis of cartilage regeneration following microfracture and mosaicplasty cartilage resurfacing procedures.
MedLine Citation:
PMID:  20882622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine T(1ρ) (T1rho) and T(2) quantitative magnetic resonance imaging (MRI) in evaluating cartilage regeneration following microfracture (MFx) and mosaicplasty (MOS) cartilage resurfacing procedures.
MATERIALS AND METHODS: Eighteen patients underwent MFx and eight patients underwent MOS to treat symptomatic focal cartilage defects. Quantitative T(1ρ) and T(2) maps were acquired at 3-6 months and 1 year after surgery. The area of resurfacing was identified, and T(1ρ) and T(2) values for the regenerated tissue (RT) and normal cartilage (NC) were acquired. RT/NC ratios were calculated to standardize absolute T(1ρ) and T(2) values. Data were prospective, cross-sectional, and nonrandomized.
RESULTS: T(1ρ) and T(2) showed good reanalysis reproducibility for RT and NC. Significant differences between RT and NC were present following MFx at 3-6 months for T(1ρ) and T(2) values as well as following MOS at 3-6 months and 1 year for T(1ρ) values. Following MFx, the T(2) RT/NC ratio was significantly different between 3-6 months and 1 year (P = 0.02), while the T(1ρ) RT/NC ratio approached significance (P = 0.07). Following MOS, the T(1ρ) and T(2) RT/NC ratios were not significantly different between the two timepoints.
CONCLUSION: T(1ρ) and T(2) MRI are complementary and reproducible methods for quantitatively and noninvasively monitoring regeneration of RT following MFx and MOS.
Authors:
Daniel J Holtzman; Alexander A Theologis; Julio Carballido-Gamio; Sharmila Majumdar; Xiaojuan Li; C Benjamin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  32     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2011-02-02     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  914-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthroplasty, Subchondral*
Automation
Cartilage / pathology
Cartilage, Articular / injuries,  pathology*
Cross-Sectional Studies
Female
Fracture Healing
Humans
Imaging, Three-Dimensional
Knee Joint / pathology*
Magnetic Resonance Imaging / methods*
Male
Prospective Studies
Regeneration*
Grant Support
ID/Acronym/Agency:
K25 AR053633/AR/NIAMS NIH HHS; R01 AR046905/AR/NIAMS NIH HHS; R01 AR046905-10/AR/NIAMS NIH HHS; R01 AR46905/AR/NIAMS NIH HHS
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