Document Detail


T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation.
MedLine Citation:
PMID:  19618188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this prospective study was to determine the oxygen saturation of blood in the fetal brain based on T2 and T2* measurements in a fetal sheep model. Five sheep fetuses were investigated during normoxia and hypoxia by 3T MRI. Multi-echo gradient-echo and turbo-spin-echo sequences were performed on the fetal brain. MR-determined oxygen saturation (MR-sO(2)) of blood in the fetal brain was calculated based on T2 and T2* values. Fetal arterial blood oxygen saturation (blood-sO(2)) was measured during the two experimental phases. The slope of MR-sO(2) as a function of blood-sO(2) was estimated and tested for compatibility using the one-sample t-test. During normoxia, mean values for carotid blood oxygen saturation were 67%, 83 ms for T2*, 202 ms for T2 and 96% for MR-sO(2). During hypoxia, arterial blood oxygen saturation, T2* and calculated MR-sO(2) decreased to 22%, 64 ms, and 68% respectively. The one-sample t-test revealed the slope to be significantly different from 0 (T = 5.023, df = 4, P = 0.007). It is feasible to perform quantitative T2 and T2* measurements in the fetal brain. MR-sO(2) and fetal arterial blood oxygen saturation correlated significantly. However, based on these data a reliable quantification of fetal brain tissue oxygenation is not possible.
Authors:
Ulrike Wedeg?rtner; Hendrik Kooijman; Thomas Andreas; Nicola Beindorff; Kurt Hecher; Gerhard Adam
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-18
Journal Detail:
Title:  European radiology     Volume:  20     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-11     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Affiliation:
Department of Diagnostic and Interventional Radiology, Universit?tsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany. wedegaer@uke.uni-hamburg.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / embryology,  metabolism*
Brain / embryology,  metabolism*
Fetal Hypoxia / diagnosis,  metabolism*
Hypoxia, Brain / diagnosis,  metabolism*
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Oxygen / blood*
Reproducibility of Results
Sensitivity and Specificity
Sheep
Statistics as Topic
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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