| T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation. | |
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MedLine Citation:
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PMID: 19618188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this prospective study was to determine the oxygen saturation of blood in the fetal brain based on T2 and T2* measurements in a fetal sheep model. Five sheep fetuses were investigated during normoxia and hypoxia by 3T MRI. Multi-echo gradient-echo and turbo-spin-echo sequences were performed on the fetal brain. MR-determined oxygen saturation (MR-sO(2)) of blood in the fetal brain was calculated based on T2 and T2* values. Fetal arterial blood oxygen saturation (blood-sO(2)) was measured during the two experimental phases. The slope of MR-sO(2) as a function of blood-sO(2) was estimated and tested for compatibility using the one-sample t-test. During normoxia, mean values for carotid blood oxygen saturation were 67%, 83 ms for T2*, 202 ms for T2 and 96% for MR-sO(2). During hypoxia, arterial blood oxygen saturation, T2* and calculated MR-sO(2) decreased to 22%, 64 ms, and 68% respectively. The one-sample t-test revealed the slope to be significantly different from 0 (T = 5.023, df = 4, P = 0.007). It is feasible to perform quantitative T2 and T2* measurements in the fetal brain. MR-sO(2) and fetal arterial blood oxygen saturation correlated significantly. However, based on these data a reliable quantification of fetal brain tissue oxygenation is not possible. |
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Authors:
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Ulrike Wedeg?rtner; Hendrik Kooijman; Thomas Andreas; Nicola Beindorff; Kurt Hecher; Gerhard Adam |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-18 |
Journal Detail:
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Title: European radiology Volume: 20 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 121-7 Citation Subset: IM |
Affiliation:
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Department of Diagnostic and Interventional Radiology, Universit?tsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany. wedegaer@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / embryology, metabolism* Brain / embryology, metabolism* Fetal Hypoxia / diagnosis, metabolism* Hypoxia, Brain / diagnosis, metabolism* Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Oxygen / blood* Reproducibility of Results Sensitivity and Specificity Sheep Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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