| T2* magnetic resonance imaging of the liver in thalassemic patients in Iran. | |
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MedLine Citation:
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PMID: 21274383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the accuracy of T2*-weighted magnetic resonance imaging (MRI T2*) in the evaluation of iron overload in beta-thalassemia major patients. METHODS: In this cross-sectional study, 210 patients with beta-thalassemia major having regular blood transfusions were consecutively enrolled. Serum ferritin levels were measured, and all patients underwent MRI T2* of the liver. Liver biopsy was performed in 53 patients at an interval of no longer than 3 mo after the MRI T2* in each patient. The amount of iron was assessed in both MRI T2* and liver biopsy specimens of each patient. RESULTS: Patients' ages ranged from 8 to 54 years with a mean of 24.59 ± 8.5 years. Mean serum ferritin level was 1906 ± 1644 ng/mL. Liver biopsy showed a moderate negative correlation with liver MRI T2* (r = -0.573, P = 0.000) and a low positive correlation with ferritin level (r = 0.350, P = 0.001). Serum ferritin levels showed a moderate negative correlation with liver MRI T2* values (r = -0.586, P = 0.000). CONCLUSION: Our study suggests that MRI T2* is a non-invasive, safe and reliable method for detecting iron load in patients with iron overload. |
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Authors:
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Farhad Zamani; Sara Razmjou; Shahram Akhlaghpoor; Seyyedeh-Masoomeh Eslami; Azita Azarkeivan; Afsaneh Amiri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-28 Completed Date: 2011-07-18 Revised Date: 2011-07-21 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 522-5 Citation Subset: IM |
Affiliation:
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Gastroenterology and Liver Disease Research Center, Firoozgar Hospital, Tehran University of Medical Sciences, Valadi Street, Valiasr Square, Tehran, Iran. zamani.farhad@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy Child Cross-Sectional Studies Female Ferritins / blood Humans Iron Overload / pathology Liver / pathology* Magnetic Resonance Imaging / methods* Male Middle Aged Young Adult beta-Thalassemia / pathology* |
| Chemical | |
Reg. No./Substance:
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9007-73-2/Ferritins |
| Comments/Corrections | |
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