| T1rho Magnetic Resonance Imaging Quantification of Early Lumbar Intervertebral Disc Degeneration in Healthy Young Adults. | |
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MedLine Citation:
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PMID: 22281486 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: Study Design. Cross-sectional study using T1rho magnetic resonance imaging (MRI) of lumbar spine in healthy young adults.Objective. To evaluate early intervertebral disc degeneration (IDD) quantified by T1ρ and T2-weighted MRI in asymptomatic young adults and to correlate T1ρ value with Pfirrmann degenerative grade, gender and body mass index (BMI).Summary of Background Data. Intervertebral disc (IVD) starts early to degenerate losing proteoglycan content in the nucleus pulposus (NP). A potential tool for the study of early stage of IDD is T1ρ MRI. T1ρ relaxation time of human discs has been correlated to proteoglycan content in previous studies.Methods. T1ρ- and T2-weighted images of the lumbar spine were obtained with a 1.5T MRI scanner of 63 asymptomatic young subjects (male 34, female 29; mean age 22.95±1.8). T1ρ mapping and values in the NP and anulus fibrosus (AF) (n = 315) were obtained. Degenerative grade was assessed using T2-weighted images according to the Pfirrmann scale. Differences in T1ρ value among gender, BMI, and linear regression analyses with degenerative grade were determined.Results. T1ρ values of NPs were significantly higher then AF at all levels. T1ρ values were significantly lower in female at L3-L4 and L4-L5 discs (p<0.05). T1ρ values decreased linearly with degenerative grade. However, non degenerated discs (Pfirrmann grade 1 and 2) showed a wide range of T1ρ relaxation time. No significant correlation was observed between T1ρ value and BMI.Conclusion. The data of this study showed a significant difference in IDD onset among gender. T1ρ values correlate with Pfirrmann degenerative grade in young adults. However, the wide distribution of T1ρ values in healthy IVD highlights the low sensitivity of Pfirrmann grade to detect the early IDD changes. T1ρ can be potentially used as a clinical tool to identify early IDD and to create a reliable quantitative scale. |
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Authors:
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Bruno Beomonte Zobel; Gianluca Vadalà; Riccardo Del Vescovo; Sofia Battisti; Francesca Maria Martina; Luigi Stellato; Emanuele Leoncini; Arijitt Borthakur; Vincenzo Denaro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Spine Volume: - ISSN: 1528-1159 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Radiology, University Campus Bio-Medico of Rome, Rome, Italy 2Department of Orthopaedic and Trauma Surgery, University Campus Bio-Medico of Rome, Rome, Italy 3Sapienza University of Rome, Rome, Italy 4CMROI, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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