| T(1ρ) MRI in Alzheimer's disease: detection of pathological changes in medial temporal lobe. | |
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MedLine Citation:
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PMID: 20331502 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values correlated with the neurological diagnosis. METHODS: MRI was performed on AD (n=48), MCI (n=45), and age-matched control (n=41), on a 1.5 Tesla Siemens clinical MRI scanner. T1ρ maps were generated by fitting each pixel's intensity as a function of the duration of the spin-lock pulse. T1ρ values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL). RESULTS: GM and WM T1ρ values were 87.5±1.2 ms and 80.5±1.4 ms, respectively, in controls, 90.9±1.3 ms and 84.1±1.7 ms in MCI, and 91.9±.8 ms and 88.3±1.3 ms in AD cohorts. Compared to control, AD patients showed 9% increased WM T1ρ and 5% increased GM T1ρ. Compared to control, MCI individuals showed 4% increased T1ρ both in WM and GM. A 5% increased T1ρ was found in WM of AD over MCI. CONCLUSION: The increased T1ρ in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI. |
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Authors:
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Mohammad Haris; Anup Singh; Kejia Cai; Erin McArdle; Matthew Fenty; Christos Davatzikos; John Q Trojanowski; Elias R Melhem; Christopher M Clark; Arijitt Borthakur |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-07-26 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: e86-90 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 by the American Society of Neuroimaging. |
Affiliation:
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CMROI, SBIA, Center for Neurodegenerative Disease Research, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104-6100, USA. harissgpgi@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / pathology* Analysis of Variance Case-Control Studies Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging / methods* Male Temporal Lobe / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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P41 RR002305-236875/RR/NCRR NIH HHS; P41 RR002305-246021/RR/NCRR NIH HHS; P41 RR002305-255549/RR/NCRR NIH HHS; P41 RR002305-26/RR/NCRR NIH HHS; RR02305/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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