Document Detail

T1198C polymorphism of the angiotensinogen gene and antihypertensive response to angiotensin-converting enzyme inhibitors.
MedLine Citation:
PMID:  16671337     Owner:  NLM     Status:  MEDLINE    
This study examined the association between T1198C polymorphism of the angiotensinogen (AGT) gene and the blood pressure response to ACE inhibitors in a Chinese hypertensive cohort. After a 2-week single-blind placebo run-in period, benazepril (10-20 mg/day) or imidapril (5-10 mg/day) was administered for 6 weeks to 509 patients with mild-to-moderate essential hypertension. Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism, and the patients were classified as having the TT, TC, or CC genotype. The achieved changes in systolic and diastolic blood pressure (SBP and DBP) were analyzed to determine their association with genotypes at the AGT gene locus. In the total 509 patients, the TT genotype was observed in 44 patients (8.7%), the TC genotype in 214 patients (42.0%), and the CC genotype in 251 patients (49.3%). The SBP reductions in patients with the TT genotype, TC genotype, and CC genotype were -15.3+/-12.7 mmHg, -14.0+/-12.7 mmHg, and -14.4+/-12.4 mmHg, respectively (p=0.809). The DBP reductions in patients with the TT genotype, TC genotype, and CC genotype were -8.5+/-8.1 mmHg, -8.3+/-7.5 mmHg, and -8.9+/-6.6 mmHg, respectively (p=0.638). There were no significant differences in the changes in SBP or DBP after treatment among the three genotype groups. In conclusion, these results suggest that the AGT genotype does not predict the blood pressure-lowering response to antihypertensive treatment with ACE inhibitors in Chinese hypertensive patients.
Huimin Yu; Shuguang Lin; Guozhang Liu; Yuqing Zhang; Chunyu Deng; Wenjun Ma
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  28     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  981-6     Citation Subset:  IM    
Department of Cardiology, Guangdong Provincial People's Hospital and Guangdong Cardiovascular Institute, Guangzhou, P.R. China.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Angiotensinogen / genetics*
Antihypertensive Agents / pharmacology
Benzazepines / pharmacology*
Blood Pressure / drug effects*,  genetics
Double-Blind Method
Hypertension / genetics
Imidazolidines / pharmacology*
Middle Aged
Polymorphism, Genetic
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Benzazepines; 0/Imidazolidines; 11002-13-4/Angiotensinogen; 86541-75-5/benazepril; 89396-94-1/imidapril

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