| T1 cortical hypointensities and their association with cognitive disability in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 20699284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Neocortical lesions (NLs) largely contribute to the pathology of multiple sclerosis (MS), although their relevance in patients' disability remains unknown. OBJECTIVE: To assess the incidence of T(1) hypointense NLs by 3.0-Tesla magnetic resonance imaging (MRI) in patients with MS and examine neocortical lesion association with cognitive impairment. METHODS: In this case-control study, 21 MS patients and 21 age-, sex- and years of education-matched healthy volunteers underwent: (i) a neuropsychological examination rating cognitive impairment (Minimal Assessment of Cognitive Function in MS); (ii) a 3.0-Tesla MRI inclusive of an isotropic 1.0 mm(3) three-dimensional inversion prepared spoiled gradient-recalled-echo (3D-IRSPGR) image and T(1)- and T(2)-weighted images. Hypointensities on 3D-IRSPGR lying in the cortex, either entirely or partially were counted and association between NLs and cognitive impairment investigated. RESULTS: A total of 95 NLs were observed in 14 (66.7%) patients. NL+ patients performed poorer (p = 0.020) than NL-patients only on the delayed recall component of the California Verbal Learning Test. This difference lost statistical significance when a correction for white matter lesion volume was employed. CONCLUSIONS: Although T( 1) hypointense NLs may be present in a relatively high proportion of multiple sclerosis patients, the impact that they have in cognitive impairment is not independent from white matter disease. |
| | |
Authors:
|
Francesca Bagnato; Zeena Salman; Robert Kane; Sungyoung Auh; Fredric K Cantor; Mary Ehrmantraut; Antonio Gallo; Vasiliki N Ikonomidou; Joan Ohayon; Clelia Pellicano; Susan K Stern; Henry F McFarland |
Related Documents
:
|
17211554 - Microbleeds on gradient-echo t2(*)-weighted mr images from patients with multiple simul... 12687814 - Programming optimal atrioventricular delay in dual chamber pacing using peak endocardia... 16687054 - Role of magnetic resonance spectroscopy in diagnosis and management of multiple sclerosis. 1977004 - Evoked potentials in assessment and follow-up of patients with wilson's disease. 21617394 - The deviation of liver dose in real patients for thoracic computed tomography scans: a ... 21796894 - An isolated hand tumour as primary manifestation of sarcoidosis. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-10 |
Journal Detail:
|
Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 16 ISSN: 1477-0970 ISO Abbreviation: Mult. Scler. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
|
Languages: eng Pagination: 1203-12 Citation Subset: IM |
Affiliation:
|
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1400, USA. bagnatof@ninds.nih.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Case-Control Studies Cerebral Cortex / pathology* Cognition Disorders / etiology, pathology*, psychology* Disability Evaluation Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / complications, pathology*, psychology* Neuropsychological Tests Verbal Learning / physiology Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of components of grape powder with anti-apoptotic effects.
Next Document: The effect of core stability training on balance and mobility in ambulant individuals with multiple ...