Document Detail


The T wave as a marker of dispersion of ventricular repolarization in premature infants before and while on treatment with the I(Kr) channel blocker cisapride.
MedLine Citation:
PMID:  11922439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Measurement of electrocardiographic intervals to assess dispersion in ventricular repolarization may be helpful in the assessment of the risk of ventricular arrhythmia. We measured QTc, QT dispersion, and T wave intervals in premature infants before and while on treatment with the I(Kr) blocker cisapride as markers for dispersion in ventricular repolarization. METHODS AND RESULTS: We enrolled 15 non-ventilated premature infants with a mean gestational age of 30.5 weeks, ranging from 26.5 to 33.5 weeks, and mean postnatal age of 24 days, with a range from 5 to 51 days. A digital 12 lead electrocardiogram was recorded prior to and 3 days after administering cisapride at a dose of 0.8 mg/kg/day. Serum electrolytes were simultaneously measured. Electrocardiographic measurements before and after included: QT, QTc Bazett, QT dispersion, R-R, T wave interval peak to end, T wave interval peak to end/onset Q to T wave peak, T wave axis, T wave maximum voltage and QRS-T angle. A paired t test and analysis of variance was used to compare the variables before and during treatment. The QTc, T wave interval peak to end and the ratio T wave interval peak to end/onset Q to T peak increased significantly following treatment with cisapride. Results expressed as before and during treatment were for QTc: 429 (65) ms versus 454 (29) ms p < 0.02; for T wave interval peak to end: 65 (11) ms versus 103 (24) p <0.01, for the ratio T wave interval peak to end/onset Q to T peak: 0.32 (0.06) versus 0.55 (0.16) p < 0.001. Treatment with the I(Kr) blocker did not significantly alter the QT dispersion, T wave voltage, angle or QRS-T angle. CONCLUSION: The interval from the peak to the end of the T wave and the ratio of this value to the onset Q to T peak interval, represents regional dispersion of repolarization across the ventricular wall. This is a potentially useful clinical index in the assessment of arrhythmic risk in premature infants being treated by blockade of the I(Kr) channels.
Authors:
Avram Benatar; Filip Cools; Tine Decraene; Adel Bougatef; Yvan Vandenplas
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Cardiology in the young     Volume:  12     ISSN:  1047-9511     ISO Abbreviation:  Cardiol Young     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-03-29     Completed Date:  2002-09-11     Revised Date:  2008-10-28    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
Affiliation:
Department of Pediatric Cardiology, Academic Hospital, Free University of Brussels, Belgium. Abraham.Benatar@az.vub.ac.be
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MeSH Terms
Descriptor/Qualifier:
Belgium
Cation Transport Proteins*
Cisapride / administration & dosage,  antagonists & inhibitors*
DNA-Binding Proteins*
Electrocardiography*
Ether-A-Go-Go Potassium Channels
Humans
Infant
Infant Welfare
Infant, Newborn
Infant, Premature*
Long QT Syndrome / complications,  drug therapy,  epidemiology
Potassium Channel Blockers*
Potassium Channels / administration & dosage
Potassium Channels, Voltage-Gated*
Risk Factors
Trans-Activators*
Ventricular Premature Complexes / epidemiology,  etiology
Chemical
Reg. No./Substance:
0/Cation Transport Proteins; 0/DNA-Binding Proteins; 0/ERG protein, human; 0/ERG1 potassium channel; 0/Ether-A-Go-Go Potassium Channels; 0/KCNH6 protein, human; 0/Potassium Channel Blockers; 0/Potassium Channels; 0/Potassium Channels, Voltage-Gated; 0/Trans-Activators; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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