| The T wave as a marker of dispersion of ventricular repolarization in premature infants before and while on treatment with the I(Kr) channel blocker cisapride. | |
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MedLine Citation:
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PMID: 11922439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Measurement of electrocardiographic intervals to assess dispersion in ventricular repolarization may be helpful in the assessment of the risk of ventricular arrhythmia. We measured QTc, QT dispersion, and T wave intervals in premature infants before and while on treatment with the I(Kr) blocker cisapride as markers for dispersion in ventricular repolarization. METHODS AND RESULTS: We enrolled 15 non-ventilated premature infants with a mean gestational age of 30.5 weeks, ranging from 26.5 to 33.5 weeks, and mean postnatal age of 24 days, with a range from 5 to 51 days. A digital 12 lead electrocardiogram was recorded prior to and 3 days after administering cisapride at a dose of 0.8 mg/kg/day. Serum electrolytes were simultaneously measured. Electrocardiographic measurements before and after included: QT, QTc Bazett, QT dispersion, R-R, T wave interval peak to end, T wave interval peak to end/onset Q to T wave peak, T wave axis, T wave maximum voltage and QRS-T angle. A paired t test and analysis of variance was used to compare the variables before and during treatment. The QTc, T wave interval peak to end and the ratio T wave interval peak to end/onset Q to T peak increased significantly following treatment with cisapride. Results expressed as before and during treatment were for QTc: 429 (65) ms versus 454 (29) ms p < 0.02; for T wave interval peak to end: 65 (11) ms versus 103 (24) p <0.01, for the ratio T wave interval peak to end/onset Q to T peak: 0.32 (0.06) versus 0.55 (0.16) p < 0.001. Treatment with the I(Kr) blocker did not significantly alter the QT dispersion, T wave voltage, angle or QRS-T angle. CONCLUSION: The interval from the peak to the end of the T wave and the ratio of this value to the onset Q to T peak interval, represents regional dispersion of repolarization across the ventricular wall. This is a potentially useful clinical index in the assessment of arrhythmic risk in premature infants being treated by blockade of the I(Kr) channels. |
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Authors:
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Avram Benatar; Filip Cools; Tine Decraene; Adel Bougatef; Yvan Vandenplas |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Cardiology in the young Volume: 12 ISSN: 1047-9511 ISO Abbreviation: Cardiol Young Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-03-29 Completed Date: 2002-09-11 Revised Date: 2008-10-28 |
Medline Journal Info:
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Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: England |
Other Details:
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Languages: eng Pagination: 32-6 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Academic Hospital, Free University of Brussels, Belgium. Abraham.Benatar@az.vub.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Belgium Cation Transport Proteins* Cisapride / administration & dosage, antagonists & inhibitors* DNA-Binding Proteins* Electrocardiography* Ether-A-Go-Go Potassium Channels Humans Infant Infant Welfare Infant, Newborn Infant, Premature* Long QT Syndrome / complications, drug therapy, epidemiology Potassium Channel Blockers* Potassium Channels / administration & dosage Potassium Channels, Voltage-Gated* Risk Factors Trans-Activators* Ventricular Premature Complexes / epidemiology, etiology |
| Chemical | |
Reg. No./Substance:
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0/Cation Transport Proteins; 0/DNA-Binding Proteins; 0/ERG protein, human; 0/ERG1 potassium channel; 0/Ether-A-Go-Go Potassium Channels; 0/KCNH6 protein, human; 0/Potassium Channel Blockers; 0/Potassium Channels; 0/Potassium Channels, Voltage-Gated; 0/Trans-Activators; 81098-60-4/Cisapride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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