Document Detail

T-wave alternans as an arrhythmic risk stratifier: state of the art.
MedLine Citation:
PMID:  23881581     Owner:  NLM     Status:  MEDLINE    
Microvolt level T-wave alternans (MTWA), a phenomenon of beat-to-beat variability in the repolarization phase of the ventricles, has been closely associated with an increased risk of ventricular tachyarrhythmic events (VTE) and sudden cardiac death (SCD) during medium- and long-term follow-up. Recent observations also suggest that heightened MTWA magnitude may be closely associated with short-term risk of impending VTE. At the subcellular and cellular level, perturbations in calcium transport processes likely play a primary role in the genesis of alternans, which then secondarily lead to alternans of action potential morphology and duration (APD). As such, MTWA may play a role not only in risk stratification but also more fundamentally in the pathogenesis of VTE. In this paper, we outline recent advances in understanding the pathogenesis of MTWA and also the utility of T-wave alternans testing for clinical risk stratification. We also highlight emerging clinical applications for MTWA.
Faisal M Merchant; Omid Sayadi; Kasra Moazzami; Dheeraj Puppala; Antonis A Armoundas
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  15     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2014-03-11     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / diagnosis*,  etiology,  physiopathology
Death, Sudden, Cardiac / etiology,  prevention & control
Electrocardiography / methods*
Risk Assessment / methods
Tachycardia, Ventricular / diagnosis,  etiology,  physiopathology
Grant Support
1R21AG035128/AG/NIA NIH HHS; R21 AG035128/AG/NIA NIH HHS

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