Document Detail


T regulatory cells in contact hypersensitivity.
MedLine Citation:
PMID:  18596584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The review summarizes the recent investigations focused on T regulatory cells in hapten diseases. RECENT FINDINGS: Multiple mechanisms ensure tolerance to small chemicals penetrating the skin. Among these, specific T regulatory cells play a major role in controlling harmful immune responses to environmental antigens. Most of the T regulatory cells involved in this process belongs to the CD4 subset and suppress hapten-specific immune response through the release of IL-10 and through direct interaction with effector T cells, blocking their function. SUMMARY: Methods for in-vitro and in-vivo expansion of specific T regulatory cells may represent an innovative approach for the cure of contact hypersensitivity.
Authors:
Andrea Cavani
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  8     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  294-8     Citation Subset:  IM    
Affiliation:
Laboratory of Immunology, IDI-IRCCS, Rome, Italy. cavani@idi.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Dermatitis, Contact / immunology*,  therapy
Disease Models, Animal*
Environmental Exposure / adverse effects
Haptens / adverse effects,  drug effects,  immunology*,  radiation effects
Humans
Immunotherapy, Adoptive / trends
Interleukin-10 / secretion
Langerhans Cells / cytology,  immunology
Mice
Self Tolerance / drug effects,  immunology*,  radiation effects
T-Lymphocytes, Regulatory / cytology*,  immunology,  metabolism
Chemical
Reg. No./Substance:
0/Haptens; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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