| T lymphocytes specific for immunoglobulin allotype. II. Cloned Igh-1b-specific cytotoxic T cells. | |
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MedLine Citation:
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PMID: 6973606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study describes long-term-cultured lines and clones of cytotoxic T cells (Tc) with specificity for determinants of the Igh-1(b) immunoglobulin allotype. These Tc clones were initiated by repeated stimulation of immune spleen cells from BALB/c mice with an Igh-1(b)-producing myeloma, and then they were maintained in medium supplemented with mitogen-induced growth factors in the absence offurther antigenic stimulation . The lytic potency of these clones was 30-100-fold greater than the primary cultures from which they were derived, and specificity studies showed them to be lytic for Igh-1(b) targets and not for targets expressing Igh-1(a) or Igh-4(b), nor the lipopolysaccharide blasts . Finally, soluble preparations of Ig were tested for their ability to block lysis of labeled Igh-1(b)-expressing targets. The results showed that Igh-1(b) and not other immunoglobulin allotypes or isotypes could block lysis, and that the mechanism of lytic inhibition is due to Igh-1(b)-induced autolysis of the killer cells. |
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Authors:
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H R Snodgrass; M J Bosma; D B Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 154 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-10-25 Completed Date: 1981-10-25 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-500 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Specificity Clone Cells / immunology Cytotoxicity, Immunologic Immunoglobulin Allotypes / immunology* T-Lymphocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI-10961/AI/NIAID NIH HHS; AI-13323/AI/NIAID NIH HHS; CA-09140/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin Allotypes |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Print publication date: Day: 1 Month: 8 Year: 1981 Volume: 154 Issue: 2 First Page: 491 Last Page: 500 ID: 2186419 Publisher Id: 1542491 PubMed Id: 6973606 |
| T lymphocytes specific for immunoglobulin allotype. II. Cloned Igh-1(b)- specific cytotoxic T cells | |
| HR Snodgrass | |
| MJ Bosma | |
| DB Wilson | |
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