Document Detail


T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells.
MedLine Citation:
PMID:  12144637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although food hypersensitivity might be divided in IgE- and non-IgE mediated food allergy, there is a large body of evidence implicating T lymphocytes overall in the pathogenesis of food allergy. Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors (l-selectin, CCR7 and CXCR4) will help to initiate diapedesis of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. Food-specific memory T cells express various surface receptors such as the alpha4beta7-integrin, or the cutaneous lymphocyte antigen. It is speculated, that they might also express specific chemokine receptors (CCR4, CCR7 or CCR9). Organ-specific homing will be facilitated through the corresponding receptors (i.e. MAdCAM-1 in the gut, VCAM-1 or fibronectin in other mucosal organs, or E-selectin in the skin). Locally secreted chemokines might help to attract T cells through their corresponding chemokine receptors. Finally, potential T-cell directed therapeutic interventions (peptide-derived immunotherapy, DNA vaccination, or strategies preventing T cells from trafficking to target organs) are discussed.
Authors:
Philippe A Eigenmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  13     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-29     Completed Date:  2003-02-19     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  162-71     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, and Division of Immunology and Allergy, University Hospital of Geneva, Geneva, Switzerland. Philippe.Eigenmann@hcuge.ch
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MeSH Terms
Descriptor/Qualifier:
Allergens
Cell Adhesion
Chemokines / metabolism
Child
Digestive System / immunology
Food Hypersensitivity / etiology,  immunology*,  therapy
Humans
Immune Tolerance
Immunologic Memory
Immunotherapy
Integrins / metabolism
Models, Immunological
Peyer's Patches / immunology
Receptors, Chemokine / metabolism
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Allergens; 0/Chemokines; 0/Integrins; 0/Receptors, Chemokine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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