Document Detail


T lymphocytes express B7 family molecules following interaction with dendritic cells and acquire bystander costimulatory properties.
MedLine Citation:
PMID:  12385029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dendritic cells (DC) play a pivotal role in the initiation, maintenance and regulation of the immune response. Here we obtained the first evidence that DC, in the absence of any foreign antigens, induce the expression of B7 family costimulatory molecules, such as CD80, CD86, B7-H1, PD-L2, B7-H3, and B7RP-1, on autologous T lymphocytes. Cell-to-cell contact between DC and T cells was needed in order to obtain this expression on T cells. De novo expressed B7 molecules on T cells were functional since B7+ T cells were able to costimulate the proliferation of highly purified T cells. While both autologous and allogeneic DC were able to induce similar levels of costimulatory molecule expression, the chemokine receptor repertoire on B7+ T cells after interaction with DC varied depending on the presence of allo-antigens during the interaction (CCR7-, CCR5+) or the absence of antigens (CCR7+, CCR5-). In accordance with this different pattern of chemokine receptors in the two conditions, we propose that, after the encounter with DC in lymphoid organs, this peculiar T cell population should reside in the T cell areas of the lymph nodes or migrate to peripheral sites of inflammation, providing a second signal for activating or switching off, respectively, naive or peripheral effector T cells.
Authors:
Guido Ferlazzo; Claudia Semino; Maurizio Meta; Francesco Procopio; Barbara Morandi; Giovanni Melioli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  32     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-01-30     Completed Date:  2003-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3092-101     Citation Subset:  IM    
Affiliation:
Laboratorio di Immunoterapia, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, CBA, Largo Rosanna Benzi, 10, I-16132 Genova, Italy. ferlazzo@cba.unige.it
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MeSH Terms
Descriptor/Qualifier:
Antigen Presentation
Antigens, CD / biosynthesis*
Antigens, CD80 / biosynthesis*
Antigens, CD86
Cell Communication / physiology*
Coculture Techniques
Dendritic Cells / physiology*
Humans
Immunophenotyping
Lymphocyte Culture Test, Mixed
Membrane Glycoproteins / biosynthesis*
Receptors, CCR5 / analysis
Receptors, CCR7
Receptors, Chemokine / analysis
T-Lymphocytes / metabolism*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD80; 0/Antigens, CD86; 0/CCR7 protein, human; 0/CD86 protein, human; 0/Membrane Glycoproteins; 0/Receptors, CCR5; 0/Receptors, CCR7; 0/Receptors, Chemokine

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