Document Detail

T lymphocytes express B7 family molecules following interaction with dendritic cells and acquire bystander costimulatory properties.
MedLine Citation:
PMID:  12385029     Owner:  NLM     Status:  MEDLINE    
Dendritic cells (DC) play a pivotal role in the initiation, maintenance and regulation of the immune response. Here we obtained the first evidence that DC, in the absence of any foreign antigens, induce the expression of B7 family costimulatory molecules, such as CD80, CD86, B7-H1, PD-L2, B7-H3, and B7RP-1, on autologous T lymphocytes. Cell-to-cell contact between DC and T cells was needed in order to obtain this expression on T cells. De novo expressed B7 molecules on T cells were functional since B7+ T cells were able to costimulate the proliferation of highly purified T cells. While both autologous and allogeneic DC were able to induce similar levels of costimulatory molecule expression, the chemokine receptor repertoire on B7+ T cells after interaction with DC varied depending on the presence of allo-antigens during the interaction (CCR7-, CCR5+) or the absence of antigens (CCR7+, CCR5-). In accordance with this different pattern of chemokine receptors in the two conditions, we propose that, after the encounter with DC in lymphoid organs, this peculiar T cell population should reside in the T cell areas of the lymph nodes or migrate to peripheral sites of inflammation, providing a second signal for activating or switching off, respectively, naive or peripheral effector T cells.
Guido Ferlazzo; Claudia Semino; Maurizio Meta; Francesco Procopio; Barbara Morandi; Giovanni Melioli
Related Documents :
11114519 - Directed differentiation of dendritic cells from mouse embryonic stem cells.
11814239 - Influence of dendritic cells on the in vitro allogeneic cytotoxic reaction of lymphoid ...
19878509 - Functional analysis of dendritic cell-t cell interaction in sarcoidosis.
17122879 - Anti-tumoral capabilities of effector cells after ifn-alpha or cpg-motif treatment of c...
11380679 - Uptake of hiv and latex particles by fresh and cultured dendritic cells and monocytes.
2848769 - Patients with adult respiratory distress syndrome (ards) demonstrate in vivo neutrophil...
19259939 - Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracel...
6456339 - In vitro induction of human suppressor t cells by a chorionic gonadotropin preparation.
7848679 - Association of alterations in nf-kappa b moieties with hiv type 1 proviral latency in c...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  32     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-01-30     Completed Date:  2003-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3092-101     Citation Subset:  IM    
Laboratorio di Immunoterapia, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, CBA, Largo Rosanna Benzi, 10, I-16132 Genova, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigen Presentation
Antigens, CD / biosynthesis*
Antigens, CD80 / biosynthesis*
Antigens, CD86
Cell Communication / physiology*
Coculture Techniques
Dendritic Cells / physiology*
Lymphocyte Culture Test, Mixed
Membrane Glycoproteins / biosynthesis*
Receptors, CCR5 / analysis
Receptors, CCR7
Receptors, Chemokine / analysis
T-Lymphocytes / metabolism*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD80; 0/Antigens, CD86; 0/CCR7 protein, human; 0/CD86 protein, human; 0/Membrane Glycoproteins; 0/Receptors, CCR5; 0/Receptors, CCR7; 0/Receptors, Chemokine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lipid rafts and T cell receptor signaling: a critical re-evaluation.
Next Document:  Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells.