Document Detail

T lymphocyte trafficking: molecules and mechanisms.
MedLine Citation:
PMID:  23276933     Owner:  NLM     Status:  MEDLINE    
Coordinated migratory events are required for the development of effective and regulated immunity. Naïve T lymphocytes are programmed to recirculate predominantly in secondary lymphoid tissue by non-specific stimuli. In contrast, primed T cells must identify specific sites of antigen location in non-lymphoid tissue to exert targeted effector responses. Following priming, T cells acquire the ability to establish molecular interactions mediated by tissue-selective adhesion and chemokine receptors (homing receptors) that facilitate their access to specific organs. Recent studies have shown that an additional level of homing specificity is provided by the induction of T cell migration into the tissue by recognition of antigen displayed by the endothelium. In addition, co-stimulatory signals have been recently shown not only to regulate T cell activation and differentiation, but also to orchestrate the anatomy of the ensuing T cell response. Similarly, the characterization of migratory patterns by regulatory T cells has been the subject of many recent studies. Here, we provide an overview of key concepts, which have contribute to unraveling the complex anatomy of T cell immunity.
Hongmei Fu; Amu Wang; Claudio Mauro; Federica Marelli-Berg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-40     Citation Subset:  IM    
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MeSH Terms
Cell Movement / immunology*
Intestinal Mucosa / cytology
Liver / immunology
Lymphocyte Activation / immunology
Lymphoid Tissue / immunology
Phosphatidylinositol 3-Kinases / physiology
Receptors, Chemokine / immunology
Receptors, Lymphocyte Homing / physiology*
Signal Transduction / physiology
T-Lymphocytes / physiology*
T-Lymphocytes, Regulatory / physiology
Grant Support
G0901084//Medical Research Council; RG/09/002/26425//British Heart Foundation; //British Heart Foundation; //Medical Research Council
Reg. No./Substance:
0/Receptors, Chemokine; 0/Receptors, Lymphocyte Homing; EC 2.7.1.-/Phosphatidylinositol 3-Kinases

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