Document Detail


T lymphocyte-synovial fibroblast interactions induced by mycobacterial proteins in rheumatoid arthritis.
MedLine Citation:
PMID:  1905130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An in vitro system was established in which single-cell suspensions of lymphocytes and synovial cells from the joints of patients with rheumatoid arthritis were cultured and produced an outgrowth of an organized inflammatory tissue with an extracellular matrix and capsule. The tissue outgrowth, which had histologic features of pannus, required the addition of mycobacterial antigen and interleukin-2 to the tissue culture medium and was dependent upon the presence of T lymphocytes and their interaction with synovial fibroblasts.
Authors:
J Holoshitz; J Kosek; R Sibley; D A Brown; S Strober
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  34     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-22     Completed Date:  1991-07-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  679-86     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Stanford University School of Medicine, CA 94305.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / pathology*,  physiopathology
Bacterial Proteins / pharmacology*
Cell Communication / drug effects*
Cells, Cultured
Fibroblasts / physiology*
Heat-Shock Proteins / pharmacology*
Humans
Microscopy, Electron, Scanning
Mycobacterium tuberculosis*
Synovial Membrane / pathology*
T-Lymphocytes / physiology*
Grant Support
ID/Acronym/Agency:
AI-11313/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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