Document Detail

T-lymphocyte subsets and their cytotoxic capacity in patients with type I and type II diabetes mellitus.
MedLine Citation:
PMID:  3492131     Owner:  NLM     Status:  MEDLINE    
Distribution and cytotoxic function of lymphocyte subpopulations were studied in 20 patients with type I, in 20 patients with type II diabetes mellitus and in 40 control subjects. The percentage, the absolute number of (EA), (E Thr), (TM) subsets and the rate of (E Thr) (E Ths) and (TM/) (TG) cells were found to be higher in type I and lower in type II diabetic patients than in controls. This opposite tendency in the distribution of T-lymphocyte subsets may be related to the duration of diabetes. Simultaneously a significant cytotoxic capacity of U, null, T, (TG)-lymphocytes was observed against human pancreas extract-coated targets in almost all 18 out of 20 of type I, but only in a few cases (5 out of 20) of type II diabetic patients. These five patients needed insulin therapy six months later. The T and (TG)-lymphocytes had the largest killer activity in both diabetic groups. Lymphocyte-mediated cytotoxicity seems to be a specific method which is suitable for the study of in vitro sensitization against pancreas tissue, and it might predict insulin dependency in type II diabetic patients.
M Horváth; M Varsányi; N Jovanovich; Z Rózsás; I Balázsi
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  14     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1986 Sep-Oct
Date Detail:
Created Date:  1987-01-28     Completed Date:  1987-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  399-405     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic
Diabetes Mellitus, Type 1 / immunology*
Diabetes Mellitus, Type 2 / immunology*
Middle Aged
Rosette Formation
T-Lymphocytes / classification*,  immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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