Document Detail

T lymphocyte co-signaling pathways of the B7-CD28 family.
MedLine Citation:
PMID:  16212919     Owner:  NLM     Status:  MEDLINE    
The past years have witnessed significant advance in our understanding of critical roles of T cell co-signals in B7-CD28 family molecules in regulating T cell activation and tolerance. New co-signaling molecules have been identified and their functions have been delineated. These co-signaling pathways play overlapping and distinct regulatory roles at various stages of a T cell response. By expressing in appropriate time and location, these pathways have different regulatory functions through independent receptors or on different subsets of lymphocytes. Precise understanding of these pathways will allow the development of novel approaches to treatment of human diseases such as cancer, viral infection, autoimmune diseases and transplantation rejection.
Shengdian Wang; Lieping Chen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  1     ISSN:  1672-7681     ISO Abbreviation:  Cell. Mol. Immunol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2005-10-10     Completed Date:  2006-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  China    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
The Sidney Kimmel Comprehensive Cancer Center, Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
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MeSH Terms
Antigens, CD
Antigens, CD28 / immunology*
Antigens, CD80 / immunology*
Antigens, CD86 / immunology*
Antigens, Differentiation / immunology
Antigens, Differentiation, T-Lymphocyte / immunology
Lymphocyte Activation
Receptors, Immunologic / immunology
Signal Transduction / physiology*
T-Lymphocyte Subsets
T-Lymphocytes / physiology*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD28; 0/Antigens, CD80; 0/Antigens, CD86; 0/Antigens, Differentiation; 0/Antigens, Differentiation, T-Lymphocyte; 0/BTLA protein, human; 0/Receptors, Immunologic; 0/cytotoxic T-lymphocyte antigen 4; 0/inducible T-cell co-stimulator

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