Document Detail


T-helper type 2 polarization among asthmatics during and following pregnancy.
MedLine Citation:
PMID:  16839404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Asthma is the most common medical condition during pregnancy. While increased production of T helper cytokines has been reported to occur in both asthma and pregnancy, the effect of T-helper type 2 (Th2) polarization on asthma symptoms during pregnancy has not been well-characterized.
OBJECTIVE: We hypothesized that systemic Th2 cytokine and chemokine polarization occurs among asthmatics to a greater extent during their pregnancy, and is associated with more severe asthma and increased Th2 polarization in the newborn.
METHODS: Fifty-six pregnant asthmatics were recruited from prenatal clinics affiliated with New York Presbyterian Hospital. Systemic production of interleukin-4, interferon-gamma, eotaxin and IP10 were measured by intracytoplasmic staining or ELISA at recruitment, peripartum and post-partum, and in the cord blood. The frequency of asthma symptoms was measured by questionnaires and compared with Th biomarkers.
RESULTS: The chemokine ratio (IP10/eotaxin) declined over the course of pregnancy (from 3.3 +/- 1.3 to 1.4 +/- 0.2, P = 0.016), but IP10 and eotaxin increased post-partum. The decrease in the chemokine ratio was associated with more frequent asthma symptoms. A non-significant trend towards decreased interferon-gamma and increased interleukin-4 production was detected. Cord blood eotaxin levels correlated with maternal levels (r = 0.35, P = 0.03). Other peripartum biomarkers were not associated with Th2 polarization nor with subsequent respiratory symptoms in the newborn.
CONCLUSION: IP10/eotaxin declined over the course of pregnancy and was associated with worse asthma symptoms. Alterations of Th1/Th2 chemokine balance during pregnancy may identify women prone to more severe asthma during pregnancy.
Authors:
D Rastogi; C Wang; C Lendor; P B Rothman; R L Miller
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  36     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-14     Completed Date:  2007-02-22     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  892-8     Citation Subset:  IM    
Affiliation:
Division of Pulmonary, Allergy, Critical Care, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / immunology*
Biological Markers / blood
Chemokine CCL11
Chemokines / biosynthesis
Chemokines, CC / biosynthesis
Cohort Studies
Cytokines / biosynthesis
Female
Fetal Blood / immunology
Humans
Infant, Newborn / immunology*
Influenza Vaccines / immunology
Postpartum Period / immunology
Pregnancy
Pregnancy Complications / immunology*
Respiration / immunology
Severity of Illness Index
Th2 Cells / immunology*
Grant Support
ID/Acronym/Agency:
1 P01 AI50514/AI/NIAID NIH HHS; P01 AI050514/AI/NIAID NIH HHS; P01 AI050514-010005/AI/NIAID NIH HHS; P01 AI050514-020005/AI/NIAID NIH HHS; RR00645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CCL11 protein, human; 0/Chemokine CCL11; 0/Chemokines; 0/Chemokines, CC; 0/Cytokines; 0/Influenza Vaccines
Comments/Corrections

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