Document Detail


T helper cell cytokine profiles in preterm labor.
MedLine Citation:
PMID:  15373758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: To compare concentrations of T-helper cell cytokines in women with preterm labor (PTL) to normal pregnancies. METHOD OF STUDY: Fourteen women with PTL and 13 women with normal pregnancies from 24 to 34 weeks were enrolled in this pilot study. Peripheral blood mononuclear cells (PBMCs) and cervical secretions were collected. PBMCs were cultured and stimulated with mitogens. Culture supernatants and cervical secretions were assayed for type 1 (interferon-gamma, IL-12) and type 2 cytokines (IL-4, IL-5, IL-10 and IL-13) using enzyme-linked immunosorbent assays. RESULTS: There were no intergroup differences in median cytokine concentrations in PBMC cultures, or in ratios of type 1/type 2 cytokines. In cervical secretions, the median concentration of IL-4 was significantly higher in control patients. CONCLUSIONS: PTL patients appeared to have an altered T-helper cytokine balance in cervical secretions. Further study of the role of cytokines produced in the adaptive response appears warranted.
Authors:
Lisa M Hollier; Marta K Rivera; Evelyn Henninger; Larry C Gilstrap; Gailen D Marshall
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  52     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-17     Completed Date:  2005-03-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  192-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas, Houston Medical School, Houston, TX, USA. lisa.m.hollier@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Cells, Cultured
Cytokines / metabolism*
Female
Humans
Obstetric Labor, Premature / metabolism*
Phytohemagglutinins / pharmacology
Pregnancy
T-Lymphocytes, Helper-Inducer / drug effects,  metabolism*
Th1 Cells / metabolism
Th2 Cells / metabolism
Grant Support
ID/Acronym/Agency:
5K12HD01277-05/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Phytohemagglutinins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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