| T-helper 2 type cytokine and soluble interleukin-2 receptor levels in seminal plasma of infertile men. | |
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MedLine Citation:
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PMID: 9272207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: The role of cell-mediated immunity (CMI) in unexplained male infertility and impaired sperm function has been explored. METHOD OF STUDY: The presence of cytokines, namely, interleukin-4 (IL-4), interleukin-6 (IL-6), and the soluble interleukin-2 receptor (SIL-2R), was investigated in seminal plasma of 18 fertile and 20 infertile subjects, using specific enzyme-linked immunoadsorbent assays. RESULTS: IL-4 was not detected. SIL-2R was detected, but the concentration difference between the fertile and infertile group was not significant. IL-6 was detected with significantly higher levels in the infertile group compared to the fertile group. IL-6 levels in seminal plasma correlated positively with leukocyte count and negatively with sperm count, motility, and morphology. CONCLUSIONS: These findings show: a) a lack of IL-4 in seminal plasma; b) similar SIL-2R levels in fertile and infertile seminal plasma; c) increased IL-6 secretion in seminal plasma of infertile subjects; and d) specific correlations of IL-6 with the main semen parameters. |
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Authors:
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R Paradisi; R Mancini; E Bellavia; E Beltrandi; A Pession; S Venturoli; C Flamigni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 38 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-10-17 Completed Date: 1997-10-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 94-9 Citation Subset: IM; X |
Affiliation:
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Department of Obstetrics, Gynaecology and Reproductive Biology, S. Orsola Hospital, University Alma Mater Studiorum of Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Infertility, Male / immunology* Interleukin-4 / analysis* Interleukin-6 / analysis* Male Middle Aged Receptors, Interleukin-2 / analysis* Semen / chemistry* Solubility Sperm Count Th2 Cells / immunology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Receptors, Interleukin-2; 207137-56-2/Interleukin-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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