Document Detail

T-helper 2 type cytokine and soluble interleukin-2 receptor levels in seminal plasma of infertile men.
MedLine Citation:
PMID:  9272207     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The role of cell-mediated immunity (CMI) in unexplained male infertility and impaired sperm function has been explored. METHOD OF STUDY: The presence of cytokines, namely, interleukin-4 (IL-4), interleukin-6 (IL-6), and the soluble interleukin-2 receptor (SIL-2R), was investigated in seminal plasma of 18 fertile and 20 infertile subjects, using specific enzyme-linked immunoadsorbent assays. RESULTS: IL-4 was not detected. SIL-2R was detected, but the concentration difference between the fertile and infertile group was not significant. IL-6 was detected with significantly higher levels in the infertile group compared to the fertile group. IL-6 levels in seminal plasma correlated positively with leukocyte count and negatively with sperm count, motility, and morphology. CONCLUSIONS: These findings show: a) a lack of IL-4 in seminal plasma; b) similar SIL-2R levels in fertile and infertile seminal plasma; c) increased IL-6 secretion in seminal plasma of infertile subjects; and d) specific correlations of IL-6 with the main semen parameters.
R Paradisi; R Mancini; E Bellavia; E Beltrandi; A Pession; S Venturoli; C Flamigni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  38     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-17     Completed Date:  1997-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM; X    
Department of Obstetrics, Gynaecology and Reproductive Biology, S. Orsola Hospital, University Alma Mater Studiorum of Bologna, Italy.
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MeSH Terms
Infertility, Male / immunology*
Interleukin-4 / analysis*
Interleukin-6 / analysis*
Middle Aged
Receptors, Interleukin-2 / analysis*
Semen / chemistry*
Sperm Count
Th2 Cells / immunology
Reg. No./Substance:
0/Interleukin-6; 0/Receptors, Interleukin-2; 207137-56-2/Interleukin-4

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