Document Detail


T helper 17 cell population in lupus erythematosus.
MedLine Citation:
PMID:  21528751     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
MATERIAL AND METHODS: A total of 15 LE patients were recruited and divided into three groups: systemic lupus erythematosus (SLE), discoid lupus (DLE) and subacute lupus (SCLE). Serum IL-17A, IL-17F and IL-23 were detected. Th17 circulating cells were evaluated by flow cytometry.
RESULTS: Serum IL-17A and IL-17F levels were higher in SLE, DLE and SCLE patients compared to healthy controls. The number of Th17 cells were higher in SLE and DLE patients (p<0.05). the number of CD3+IL-17+ cells were higher in SLE, DLE and SCLE patients (p<0.05).
CONCLUSION: Th17 lymphocytes are implicated in LE pathogenesis. Our findings suggest that IL-17 is implicated not only in SLE but also in DLE and SCLE immunopathogenesis.
Authors:
P Bălănescu; Eugenia Bălănescu; C Tănăsescu; Adriana Nicolau; R Tănăsescu; Camelia Grancea; Codruţa Vagu; Simona Ruţă; Coralia Bleoţu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  48     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2010  
Date Detail:
Created Date:  2011-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  255-9     Citation Subset:  IM    
Affiliation:
Colentina Clinical Hospital, Bucharest, Romania. plbalanescu@gmail.com
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