| T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production. | |
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MedLine Citation:
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PMID: 2521345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To further define requirements for T cell help in the stimulation of an in vivo IgE response, we studied a system in which the injection of mice with a goat antibody to mouse IgD (GaMD) stimulates large polyclonal IgG1 and IgE responses. In this system, both responses are blocked by anti-CD4 antibody, but only the IgE response is blocked by (anti-IL-4) antibody. Anti-CD4 antibody, if injected 5 days after GaMD, was found to inhibit the GaMD-induced IgE response to a much greater extent than the IgG1 response, even though both responses occur simultaneously and are inhibited to an equal extent by optimal or suboptimal doses of anti-CD4 antibody administered 2 days after GaMD. Even a suboptimal, 50-micrograms dose of anti-CD4 antibody, when injected 5 days after GaMD, inhibited the IgE response to a much greater extent than did an optimal 10-mg dose of anti-IL-4 antibody injected at the same time, even though 10 mg of anti-IL-4 antibody more completely inhibited GaMD-induced IgE production than did 50 micrograms of anti-CD4 antibody when injected 2 days after GaMD. These observations provide evidence that a late acting form of T cell help other than IL-4 is important for the generation of an IgE response but not an IgG1 response in GaMD-immunized mice. |
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Authors:
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F D Finkelman; J Holmes; J F Urban; W E Paul; I M Katona |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 142 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-02-14 Completed Date: 1989-02-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 403-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Uniformed Services, University of the Health Sciences, Bethesda, MD 20814. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / administration & dosage Antigens, Differentiation, T-Lymphocyte / immunology B-Lymphocytes / immunology, metabolism Binding, Competitive Dose-Response Relationship, Immunologic Female Immunoglobulin E / biosynthesis* Immunoglobulin G / biosynthesis* Injections, Intravenous Interleukin-4 Interleukins / immunology, pharmacology* Kinetics Lymphocyte Activation* Mice Mice, Inbred BALB C Nematode Infections / immunology, metabolism Nippostrongylus T-Lymphocytes, Helper-Inducer / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R01-A121328//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, Differentiation, T-Lymphocyte; 0/Immunoglobulin G; 0/Interleukins; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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