Document Detail


T cells that promote B-Cell maturation in systemic autoimmunity.
MedLine Citation:
PMID:  22500839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Follicular helper T (Tfh) cells play an essential role in helping B cells generate antibodies upon pathogen encounters. Such T-cell help classically occurs in germinal centers (GCs) located in B-cell follicles of secondary lymphoid organs, a site of immunoglobulin affinity maturation and isotype switching. B-cell maturation also occurs extrafollicularly, in the red pulp of the spleen and medullary cords in lymph nodes, with plasma cell formation and antibody production. Development of extrafollicular foci (EF) in T-cell-dependent (TD) immune responses is reliant upon CD4(+) T cells with characteristics of Tfh cells. Pathogenic autoantibodies, arising from self-reactive B cells having undergone somatic hypermutation with affinity selection and class switching within GCs and EF, are major contributors to the end-organ injury in systemic autoimmunity. B cells maturing to produce autoantibodies in systemic autoimmune diseases, like those in normal immune responses, largely require T-helper cells. This review highlights Tfh cell development as an introduction to a more in-depth discussion of human Tfh cells and blood borne cells with similar features and the role of these cells in promotion of systemic autoimmunity.
Authors:
Jason S Weinstein; Sairy G Hernandez; Joe Craft
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  247     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-10     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  160-71     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity*
B-Lymphocytes / cytology*,  immunology*
Cell Differentiation*
Gene Expression Regulation
Germinal Center / cytology,  immunology
Humans
Models, Biological
T-Lymphocytes, Helper-Inducer / cytology,  immunology
Grant Support
ID/Acronym/Agency:
F31AI081516/AI/NIAID NIH HHS; P30 AR053495/AR/NIAMS NIH HHS; P30 AR053495/AR/NIAMS NIH HHS; P30 AR053495-05/AR/NIAMS NIH HHS; R01 AI075157/AI/NIAID NIH HHS; R01 AI075157-05/AI/NIAID NIH HHS; R01 AR040072/AR/NIAMS NIH HHS; R01 AR040072-22/AR/NIAMS NIH HHS; R01 AR044076/AR/NIAMS NIH HHS; R01 AR044076-15/AR/NIAMS NIH HHS; R01 AR40072/AR/NIAMS NIH HHS; R01 AR44076/AR/NIAMS NIH HHS; R21 AR062842/AR/NIAMS NIH HHS; R21 AR063942/AR/NIAMS NIH HHS; T32 AR007107/AR/NIAMS NIH HHS
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