| T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. | |
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MedLine Citation:
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PMID: 18565470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We discuss a 53-year-old woman with systemic lupus erythematosus who presented with vasculitis, hypocomplementemia and nephritis. Although her serum complement 4 (C4) levels were zero, she had four copies of C4 gene. Renal biopsy revealed membranoproliferative glomerulonephritis and the presence of cryoglobulins, detected by electron microscopy, and significant numbers of T cells in the interstitium. Cryoglobulins were considered responsible for the complete consumption of C4 in the serum the levels of which improved gradually after treatment. T cells in the kidney were found to express CD44 and phosphorylated ezrin/radixin/moiesin which explain why they homed to the kidney inappropriately. The contribution of cryoglobulins and T cells in the expression of kidney pathology is discussed. |
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Authors:
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Robert A Cohen; George Bayliss; Jose C Crispin; Gwen F Kane-Wanger; Christine A Van Beek; Vasileios C Kyttaris; Ingrid Avalos; C Yung Yu; George C Tsokos; Isaac E Stillman |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 128 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-20 Completed Date: 2008-07-15 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Antigens, CD44 / metabolism Complement C4 / deficiency Cryoglobulins / metabolism* Female Fluorescent Antibody Technique Humans Lupus Nephritis / immunology*, pathology*, physiopathology* Microscopy, Electron, Transmission Middle Aged Mycophenolic Acid / analogs & derivatives, therapeutic use Prednisone / therapeutic use T-Lymphocytes / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI042269-12A1/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antigens, CD44; 0/CD44 protein, human; 0/Complement C4; 0/Cryoglobulins; 128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid; 53-03-2/Prednisone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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