Document Detail


T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis.
MedLine Citation:
PMID:  18565470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We discuss a 53-year-old woman with systemic lupus erythematosus who presented with vasculitis, hypocomplementemia and nephritis. Although her serum complement 4 (C4) levels were zero, she had four copies of C4 gene. Renal biopsy revealed membranoproliferative glomerulonephritis and the presence of cryoglobulins, detected by electron microscopy, and significant numbers of T cells in the interstitium. Cryoglobulins were considered responsible for the complete consumption of C4 in the serum the levels of which improved gradually after treatment. T cells in the kidney were found to express CD44 and phosphorylated ezrin/radixin/moiesin which explain why they homed to the kidney inappropriately. The contribution of cryoglobulins and T cells in the expression of kidney pathology is discussed.
Authors:
Robert A Cohen; George Bayliss; Jose C Crispin; Gwen F Kane-Wanger; Christine A Van Beek; Vasileios C Kyttaris; Ingrid Avalos; C Yung Yu; George C Tsokos; Isaac E Stillman
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  128     ISSN:  1521-7035     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-07-15     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / therapeutic use
Antigens, CD44 / metabolism
Complement C4 / deficiency
Cryoglobulins / metabolism*
Female
Fluorescent Antibody Technique
Humans
Lupus Nephritis / immunology*,  pathology*,  physiopathology*
Microscopy, Electron, Transmission
Middle Aged
Mycophenolic Acid / analogs & derivatives,  therapeutic use
Prednisone / therapeutic use
T-Lymphocytes / immunology*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 AI042269/AI/NIAID NIH HHS; R01 AI042269-12A1/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antigens, CD44; 0/CD44 protein, human; 0/Complement C4; 0/Cryoglobulins; 9242ECW6R0/mycophenolate mofetil; HU9DX48N0T/Mycophenolic Acid; VB0R961HZT/Prednisone
Comments/Corrections

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