Document Detail

T cells in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  18266871     Owner:  NLM     Status:  MEDLINE    
The inflammatory process in ALS involves infiltration of T cells and activation of antigen presenting cells co-localizing with motor neuron damage in the brain and spinal cord. The role of T cells in the pathogenic process is not settled. T cells may damage motor neurons by cell-cell contact or cytokine secretion, or contribute indirectly to motor neuron damage through activation of microglia and macrophages. Alternatively, T cell infiltration may be an epiphenomenon related to clearance of dead motor neurons. Lessons from animal models of neuroinflammation and neurodegeneration have shown that T cell responses can be neuroprotective or even enhance neurogenesis. Therefore, it is possible that T cells can be induced to slow motor neuron destruction and facilitate repair in ALS. The T cell modulating drug glatiramer acetate has shown promising results in animal models, and is being currently investigated in a phase II trial in ALS. This paper reviews the evidence for T cells as pathogenic players and therapeutic targets in ALS.
T Holmøy
Publication Detail:
Type:  Journal Article; Review     Date:  2008-02-11
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  15     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  360-6     Citation Subset:  IM    
Department of Neurology, Institute of Immunology, University of Oslo, Ullevål University Hospital, Oslo, Norway.
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MeSH Terms
Amyotrophic Lateral Sclerosis / drug therapy,  pathology*
Cytokines / metabolism
Disease Models, Animal
Immunosuppressive Agents / pharmacology,  therapeutic use
Motor Neurons / drug effects,  pathology
Peptides / pharmacology,  therapeutic use
T-Lymphocytes / drug effects,  physiology*
Reg. No./Substance:
0/Cytokines; 0/Immunosuppressive Agents; 0/Peptides; 0/copolymer 1

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