| T-cell subsets in multiple sclerosis: lack of correlation between helper and suppressor T cells and the clinical state. | |
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MedLine Citation:
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PMID: 3156873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral blood T-lymphocyte subsets were investigated in a group of 26 multiple sclerosis (MS) patients of different clinical categories and compared to those of 15 normal controls and 7 other patients with known immunoregulatory disorders. In addition 17 well-documented acute relapses in 11 MS patients were also studied, some of whom were tested serially prior to, during, and after the acute attack. Using three different commercial preparations of monoclonal antibodies directed against human T3, T4, and T8 lymphocyte markers, none of the MS patients irrespective of disease category exhibited any changes in the absolute numbers of T-cell subsets or ratios thereof; this was true during either quiescent or active stages of the disease. In contrast, several patients with known immunoregulatory disorders exhibited clear changes in T4/T8 ratios. Factors such as type of patient studied, sampling error, and methods of isolation of mononuclear cells, as well as source of monoclonal antibody, failed to explain the lack of change in T-cell subsets in these patients. Thus, our data fail to confirm the previous reports of a decrease in the absolute numbers of T8 cells or the increase in the T4/T8 ratios in active or quiescent MS patients. These negative findings underscore the need for further studies relating these markers to meaningful functional properties of these cells and their interaction with the relevant target organs. |
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Authors:
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J B Zabriskie; L Mayer; S M Fu; C Yeadon; V Cam; C Plank |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of clinical immunology Volume: 5 ISSN: 0271-9142 ISO Abbreviation: J. Clin. Immunol. Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-04-26 Completed Date: 1985-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 7-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Monoclonal Humans Multiple Sclerosis / blood, immunology* T-Lymphocytes / classification T-Lymphocytes, Helper-Inducer / immunology* T-Lymphocytes, Regulatory / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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