| T-cell subpopulations in childhood nephrotic syndrome. | |
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MedLine Citation:
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PMID: 8050203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to clarify the T-cell abnormalities present in minimal-change nephrotic syndrome (MCNS), lymphocyte subsets were studied using two-color flow cytometry in children with MCNS and nephrotic syndrome caused by other types of glomerular disease, and normal healthy children. In MCNS, CD4+Leu8+ (suppressor-inducer) and CD3+CD25+ (IL-2 receptor positive T) cells were significantly increased, and CD4+Leu8- (helper-inducer), CD8+CD11+ (suppressor), CD3+HLA-DR+ (DR positive T) and CD4+HLA-DR+ (activated helper/inducer) cells were significantly decreased in comparison with normal healthy children. The same abnormalities were also found in nephrotic syndrome caused by other types of glomerular disease. These findings indicate that abnormalities of lymphocyte subsets are present in MCNS and nephrotic syndrome due to a variety of glomerular diseases, and suggest that such abnormalities are a consequence of nephrotic syndrome. |
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Authors:
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K Kobayashi; N Yoshikawa; H Nakamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 41 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-09-07 Completed Date: 1994-09-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 253-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Kobe University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Flow Cytometry Humans Infant Nephrosis, Lipoid / immunology* Nephrotic Syndrome / immunology T-Lymphocyte Subsets / immunology* |
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