Document Detail


T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.
MedLine Citation:
PMID:  19561106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infection with the obligate intracellular bacterium Chlamydia trachomatis is controlled primarily by IFN-gamma and Th1 immunity. In this study, we used cells from a Chlamydia-specific CD4(+) TCR-transgenic mouse to assess the role of IFN-gamma in development of Th1 immunity. We show that secretion of host IFN-gamma or the ability of host cells to respond to secreted IFN-gamma is not required to initiate a Th1 immune response. Additionally, we found that Ag-specific CD4(+) cells that were preskewed toward Th1 confer protection, whereas cells preskewed toward Th2 cause a previously unreported exacerbation of disease leading to higher bacterial load. Chlamydia-specific Th1 cells transferred into an IFN-gamma(-/-) recipient mouse demonstrate protective effects, but the same cells exacerbate bacterial burden when transferred into IFN-gammaR(-/-) mice. Thus, we demonstrate that the secretion of IFN-gamma is necessary for protection against C. trachomatis and that in the absence of host cell IFN-gammaR expression, both Th1 and Th2 cells lead to increased burden of C. trachomatis.
Authors:
David C Gondek; Nadia R Roan; Michael N Starnbach
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Publication Detail:
Type:  Journal Article     Date:  2009-06-26
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  183     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-07     Completed Date:  2009-09-15     Revised Date:  2012-11-16    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1313-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chlamydia Infections / immunology*
Chlamydia trachomatis*
Female
Interferon-gamma / deficiency,  immunology*
Mice
Mice, Knockout
Receptors, Interferon / deficiency,  immunology*
T-Lymphocytes / immunology*
Th1 Cells / immunology
Th2 Cells
Uterine Diseases / microbiology*
Grant Support
ID/Acronym/Agency:
F32 AI081429/AI/NIAID NIH HHS; F32 AI081429-01A1/AI/NIAID NIH HHS; R01 AI039558-06/AI/NIAID NIH HHS; R01 AI039558-07/AI/NIAID NIH HHS; R01 AI039558-08/AI/NIAID NIH HHS; R01 AI039558-09/AI/NIAID NIH HHS; T32 AI007061/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Interferon; 0/interferon gamma receptor; 82115-62-6/Interferon-gamma
Comments/Corrections

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