Document Detail


T-cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy.
MedLine Citation:
PMID:  11986226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The origin of T cells after highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus 1 (HIV-1) is now under discussion. The possibility of renewed lymphopoiesis in aged thymuses is still controversial. In this work we combine the analysis of naïve T cells, T-cell receptor excision circles (TRECs), and computed tomography scanning of thymic tissue to further assess whether the thymus is involved in immune reconstitution. Fifteen antiretroviral-naïve HIV-1-infected patients were evaluated during 48 weeks of HAART. At baseline, significant correlation was present among age and both thymic volume and TRECs, and between naïve T cells and TRECs. After starting HAART, there was a significant increase at week 12 in naïve CD4(+) and CD8(+) T cells, TRECs, and thymic volume. The initial net increases in naïve T cells and TREC counts were significantly correlated. Changes in thymic volume and TRECs were also indirectly related; splitting the population into 2 groups of high and low baseline TREC levels, only the group with low TREC levels had significant increases in both TRECs and thymic volume. Thus, the increase in thymic volume might be functional, in response to depleted TREC levels. Taken together, our data strongly suggest a thymic role in immune reconstitution, at least in patients with depleted baseline TREC levels. (Blood. 2002;99:3702-3706)
Authors:
Jaime M Franco; Amalia Rubio; Manuel Martínez-Moya; Manuel Leal; Elena Merchante; Armando Sánchez-Quijano; Eduardo Lissen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood     Volume:  99     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-02     Completed Date:  2002-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3702-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Seville, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiretroviral Therapy, Highly Active*
Female
HIV Infections / drug therapy,  immunology*,  radiography
HIV-1*
Humans
Kinetics
Leukopoiesis
Lymphocyte Count
Male
Middle Aged
T-Lymphocytes / immunology*
Thymus Gland / immunology*,  radiography
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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