Document Detail

T-cell recognition of lipid peroxidation products breaks tolerance to self proteins.
MedLine Citation:
PMID:  10540227     Owner:  NLM     Status:  MEDLINE    
Peroxidation of polyunsaturated fatty acids in lipoproteins and cell membrane phospholipids occurs in many situations in the body, both under normal and pathological conditions. Low-density lipoprotein is particularly prone to oxidation and is believed to be a pathogenetic component in atherogenesis. Both antibody responses and T-cell responses to oxidatively modified lipoproteins have been demonstrated in humans as well as in animal models. However, little is known about how these responses arise or how T cells recognize these antigens. In the present study, mice were immunized with homologous albumin covalently modified with a series of defined aldehydes which are known to be generated during lipid peroxidation. T-cell hybridomas from immunized animals demonstrated major histocompatibility complex-restricted and protein sequence-dependent responses to modified albumin, but not to native albumin. In addition to the response to modified epitopes, some aldehyde modifications resulted in strong antibody responses also to the non-modified protein. This T-cell-dependent break of tolerance constitutes a novel pathway for induction of autoimmunity by lipid peroxidation. The findings have implications in many situations where lipid peroxidation products are generated, including atherosclerosis and inflammatory and infectious diseases.
D M Wuttge; M Bruzelius; S Stemme
Related Documents :
15203197 - Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in ...
19602037 - A prospective study of macrophage migration inhibitory factor as a marker of inflammato...
9504407 - Aluminum taken up by transferrin-independent iron uptake affects the iron metabolism in...
2303437 - Apolipoprotein e and lipoprotein lipase secreted from human monocyte-derived macrophage...
22451727 - Anti-apoptotic effects of serpin b3 and b4 via stat6 activation in macrophages after in...
21438847 - Ginsenoside rg1 protects primary cultured rat hippocampal neurons from cell apoptosis i...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  98     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Cardiovascular Research Unit, Center for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aldehydes / pharmacology*
Antigens / administration & dosage
B-Lymphocytes / immunology
Blotting, Western
Interleukin-2 / immunology
Lipid Peroxidation*
Lymphocyte Activation / drug effects*
Mice, Inbred BALB C
Mice, Inbred C57BL
Self Tolerance / drug effects*
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Aldehydes; 0/Antigens; 0/Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adju...
Next Document:  Inhibitory effects of endogenous and exogenous interferon-gamma on bronchial hyperresponsiveness, al...