| T-cell-receptor-dependent actin regulatory mechanisms. | |
| | |
MedLine Citation:
|
PMID: 17314246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Following stimulation, T cells undergo marked changes in actin architecture that are required for productive immune responses. T-cell-receptor-dependent reorganization of the actin cytoskeleton is necessary for the formation of the immunological synapse at the T-cell-antigen-presenting-cell contact site and the distal pole complex at the opposite face of the T cell. Convergence of specific signaling molecules within these two plasma membrane domains facilitates downstream signaling events leading to full T-cell activation. Recent studies have identified many of the relevant actin-regulatory proteins, and significant progress has been made in our understanding of how these proteins choreograph molecular movements associated with T-cell activation. Proteins such as WASp, WAVE2, HS1 and cofilin direct the formation of a cortical actin scaffold at the immune synapse, while actin-binding proteins such as ezrin and moesin direct binding of signaling molecules to actin filaments within the distal pole complex. |
| | |
Authors:
|
Yanping Huang; Janis K Burkhardt |
Related Documents
:
|
1970736 - Do cd2 and cd3-tcr t-cell activation pathways function independently? 19531546 - Ca2+ influx and phosphoinositide signalling are essential for the establishment and mai... 10706446 - Cd148, a new membrane tyrosine phosphatase involved in leukocyte function. 11029076 - Spatial organization of microbial biofilm communities. 21796416 - Synergistic interaction between sunitinib and docetaxel is sequence dependent in human ... 17337716 - Activation and nuclear translocation of erk in response to ligand-dependent and -indepe... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Journal of cell science Volume: 120 ISSN: 0021-9533 ISO Abbreviation: J. Cell. Sci. Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-22 Completed Date: 2007-07-31 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: England |
Other Details:
|
Languages: eng Pagination: 723-30 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, 816D Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Actin Depolymerizing Factors
/
metabolism,
physiology Actins / metabolism, physiology* Animals Humans Lymphocyte Activation / physiology Microfilament Proteins / metabolism, physiology Models, Biological Receptors, Antigen, T-Cell / physiology* T-Lymphocytes / metabolism, physiology Wiskott-Aldrich Syndrome Protein Family / metabolism, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
R01-AI 50098/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Actin Depolymerizing Factors; 0/Actins; 0/Microfilament Proteins; 0/Receptors, Antigen, T-Cell; 0/Wiskott-Aldrich Syndrome Protein Family; 144131-77-1/moesin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: WRN at telomeres: implications for aging and cancer.
Next Document: The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein fo...