Document Detail


T cell phenotypes in patients with common variable immunodeficiency disorders: associations with clinical phenotypes in comparison with other groups with recurrent infections.
MedLine Citation:
PMID:  23039891     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Common variable immunodeficiency disorders (CVID) are a group of heterogeneous conditions that have in common primary failure of B cell function, although numerous T cell abnormalities have been described, including reduced proliferative response and reduced regulatory T cells. This study compared the T cell phenotype of CVID patients subdivided into clinical phenotypes as well as patients with partial antibody deficiencies [immunoglobulin (Ig)G subclass deficiency and selective IgA deficiency], X-linked agammaglobulinaemia (XLA) and healthy and disease controls. Absolute numbers of T cell subpopulations were measured by four-colour flow cytometry: naive T cells, central and effector memory and terminally differentiated (TEM) T cells, using CD45RA and CCR7 expression. Early, intermediate and late differentiation status of T cells was measured by CD27/CD28 expression. Putative follicular T cells, recent thymic emigrants and regulatory T cells were also assessed. Significant reduction in naive CD4 T cells, with reduced total CD4 and recent thymic emigrant numbers, was observed in CVID patients, most pronounced in those with autoimmune cytopenias or polyclonal lymphoproliferation. These findings suggest a lack of replenishment by new thymically derived cells. CD8 naive T cells were reduced in CVID patients, most significantly in the autoimmune cytopenia subgroup. There was a reduction in early differentiated CD4 and CD8 T cells and increased CD8 TEM in the CVID patients, particularly autoimmune cytopenia and polyclonal lymphoproliferation subgroups, suggesting a more activated T cell phenotype, due perhaps to an antigen-driven process. XLA patients had significantly reduced putative follicular T cells, which may depend on B cells for survival, while no significant alterations were observed in the T cells of those with IgG subclass deficiency or selective IgA deficiency.
Authors:
E A L Bateman; L Ayers; R Sadler; M Lucas; C Roberts; A Woods; K Packwood; J Burden; D Harrison; N Kaenzig; M Lee; H M Chapel; B L Ferry
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  170     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-18     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  202-11     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Affiliation:
Department of Clinical Laboratory Immunology, Churchill Hospital Clinical Immunology, John Radcliffe Hospital, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Agammaglobulinemia / immunology
Aged
Aged, 80 and over
Antigens, CD / immunology
B-Lymphocyte Subsets / immunology
Cell Differentiation / immunology
Child
Child, Preschool
Common Variable Immunodeficiency / immunology*
Female
Genetic Diseases, X-Linked / immunology
Humans
Immunoglobulin A / immunology
Immunoglobulin G / immunology
Infant
Lymphocyte Activation / immunology
Male
Middle Aged
Phenotype
Receptors, CCR7 / immunology
T-Lymphocyte Subsets / immunology*
Young Adult
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/CCR7 protein, human; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Receptors, CCR7
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