| T-cell movement on the reticular network. | |
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MedLine Citation:
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PMID: 22100488 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The idea that the apparently random motion of T cells in lymph nodes is a result of movement on a reticular network (RN) has received support from dynamic imaging experiments and theoretical studies. We present a mathematical representation of the RN consisting of edges connecting vertices that are randomly distributed in three-dimensional space, and models of lymphocyte movement on such networks including constant speed motion along edges and Brownian motion, not in three-dimensional, but only along edges. The simplest model, in which a cell moves with a constant speed along edges, is consistent with mean-squared displacement proportional to time over intervals long enough to include several changes of direction. A non-random distribution of turning angles is one consequence of motion on a preformed network. Confining cell movement to a network does not, in itself, increase the frequency of cell-cell encounters. |
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Authors:
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Graham M Donovan; Grant Lythe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-12 |
Journal Detail:
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Title: Journal of theoretical biology Volume: - ISSN: 1095-8541 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Mathematics, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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