Document Detail


T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma.
MedLine Citation:
PMID:  20382409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physiologic expression of the product of the proto-oncogene TCL1 (T-cell leukemia 1) is primarily restricted to early embryonic cells. In nonneoplastic B cells, the expression of TCL1 is determined by the differentiation step with silencing at the germinal center stage. TCL1 protein is overexpressed in a wide variety of human diseases. It has been shown that TCL1 is a powerful B-cell oncogene, which has been implicated in the pathogenesis of various types of mature B-cell lymphomas. There is no comparative information in the literature addressing the expression of TCL1 in pediatric and adult nodal diffuse large B-cell lymphoma or primary mediastinal large B-cell lymphoma. We studied 55 cases of adult and pediatric diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma to analyze the phenotypic profile of these lymphomas, including TCL1 expression, and its relationship with clinical outcome in different age groups. The cases were analyzed by immunohistochemistry for the expression of TCL1, CD10, BCL-2, BCL-6, and MUM1. We also evaluated c-MYC translocation by fluorescence in situ hybridization. TCL1 was observed in 11 cases, 5 pediatric and 6 adult cases, all but one diffuse large B-cell lymphoma. Pediatric cases showed a significant association between TCL1 expression, high proliferative index, and presence of c-MYC translocation. TCL1 positivity was predominantly found in germinal center phenotype diffuse large B-cell lymphoma. Overall survival was worse in adult TCL1-positive cases than pediatric ones. Primary mediastinal large B-cell lymphomas infrequently expressed TCL1 in both age groups.
Authors:
Gabriela Gualco; Lawrence M Weiss; Glen N Barber; Carlos E Bacchi
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Publication Detail:
Type:  Journal Article     Date:  2010-04-10
Journal Detail:
Title:  Human pathology     Volume:  41     ISSN:  1532-8392     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1238-44     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Consultoria em Patologia, Botucatu, SP 18602-010, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Epstein-Barr Virus Infections / metabolism*,  pathology
Female
Genes, myc
Herpesvirus 4, Human / isolation & purification*
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymph Nodes / metabolism,  pathology
Lymphoma, B-Cell / metabolism*,  pathology,  virology
Lymphoma, Large B-Cell, Diffuse / metabolism*,  pathology,  virology
Male
Mediastinal Neoplasms / metabolism*,  pathology,  virology
Middle Aged
Neoplasm Staging
Phenotype
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-myc / genetics,  metabolism
Survival Rate
Translocation, Genetic
Tumor Markers, Biological / metabolism
Young Adult
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-myc; 0/TCL1A protein, human; 0/Tumor Markers, Biological

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