| T-cell large granular lymphocyte leukemia: an Asian perspective. | |
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MedLine Citation:
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PMID: 20084380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most common indication for treatment. Neutropenia was only found in 8/22 (36%) cases, and recurrent infections, the most important clinical problem in Western patients, were not observed. None of our cases presented with rheumatoid arthritis. These clinical features were consistently observed when compared with the 88 other Asian patients. Combined data from our cohort and other Asian cases showed that Asian patients, compared with Western patients, had more frequent anemia (66/110, 60% versus 113/240, 47%; p=0.044), attributable to a much higher incidence of PRCA (52/110, 47% versus 6/143, 4%; p<0.001). However, Western patients presented more frequently than Asian patients with neutropenia (146/235, 62% versus 33/110, 30%; p<0.001) and splenomegaly (99/246, 40% versus 16/110, 15%; p< 0.001). Notably, Western patients were about eight to ten times more likely than Asian patients to have rheumatoid arthritis (73/272, 27% versus 4/106, 4%; p<0.001) and recurrent infections (81/272, 30% versus 3/107, 3%; p<0.001). These clinicopathologic differences have important implications on disease pathogenesis and treatment. |
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Authors:
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Yok-Lam Kwong; Wing-Yan Au; Anskar Y H Leung; Eric W C Tse |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of hematology Volume: 89 ISSN: 1432-0584 ISO Abbreviation: Ann. Hematol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 331-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China. ylkwong@hkucc.hku.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / therapeutic use Cohort Studies Female Hong Kong / epidemiology Humans Leukemia, Large Granular Lymphocytic / diagnosis, drug therapy, epidemiology* Male Middle Aged Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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