Document Detail


T-cell identification of a private DQw5 subtype associated with DR1: contribution of endogenous peptide?
MedLine Citation:
PMID:  2784428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human allospecific T-cell clones were generated against DR1 and DQw1 by limiting dilution. In proliferation experiments using a large panel of Epstein-Barr virus-transformed B-cell lines (LCL), eight T-cell clones (TLC) were found that responded only to the DR1+ LCLs* (9 of 9) and not the 94 other LCLs expressing DR specificities 2 through w9. TLCs* were analyzed further using monoclonal antibodies in blocking studies. As expected, most TLCs were blocked by anti-DR monoclonal antibodies (MoAbs)* and not by anti-DQ MoAbs. However, one clone, TLC 63.138, was not blocked by anti-DR MoAbs but was completely inhibited by anti-DQ MoAbs. This suggests that TLC 63.138 recognizes a private determinant on DQ molecules uniquely associated with DR1.
Authors:
T W Sell; D D Eckels
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human immunology     Volume:  24     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-03     Completed Date:  1989-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-28     Citation Subset:  IM    
Affiliation:
Immunogenetics Research Section, Blood Center of Southeastern Wisconsin, Milwaukee 53233.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal
Cells, Cultured
HLA-DQ Antigens / analysis*
HLA-DR Antigens / analysis*
Humans
Leukocytes, Mononuclear / immunology
T-Lymphocytes / classification*
Grant Support
ID/Acronym/Agency:
AI 22832/AI/NIAID NIH HHS; AI00799/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/HLA-DQ Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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