| T-cell function in chronic lymphocytic leukaemia. | |
| | |
MedLine Citation:
|
PMID: 20920582 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
According to the immune-surveillance hypothesis, cancer cells evolve strategies to evade or suppress the immune system as part of the development of this disease. The malignant B-cells of chronic lymphocytic leukaemia are prime examples of this premise, having been shown to generate a variety of ways of suppressing T-cell anti-tumour immune responses and these are summarized here. These mechanisms range from impairment of antigen presentation by the tumour cells themselves, to suppression of the immune microenvironment by contact dependent pathways and alterations in the cytokine milieu. By understanding these defects, novel targeted therapies can be developed with the aim of restoring T-cell function. Indeed, some of the recent advances in the treatment of chronic lymphocytic leukaemia have been demonstrated to have profound immunomodulatory effects, repairing these defects in T-cell function. |
| | |
Authors:
|
John C Riches; Alan G Ramsay; John G Gribben |
Publication Detail:
|
Type: Journal Article Date: 2010-10-27 |
Journal Detail:
|
Title: Seminars in cancer biology Volume: 20 ISSN: 1096-3650 ISO Abbreviation: Semin. Cancer Biol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010218 Medline TA: Semin Cancer Biol Country: England |
Other Details:
|
Languages: eng Pagination: 431-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010. Published by Elsevier Ltd. |
Affiliation:
|
Institute of Cancer, Barts and The London School of Medicine, Charterhouse Square, London, United Kingdom. j.c.riches@qmul.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Both UDP N-acetylglucosamine pyrophosphorylases of Tribolium castaneum are critical for molting, sur...
Next Document: Macromolecular docking restrained by a small angle X-ray scattering profile.