Document Detail

T-cell epitope determination.
MedLine Citation:
PMID:  8729448     Owner:  NLM     Status:  MEDLINE    
Synthetic approaches to T-cell epitope determination have recently been developed that complement the search for natural T-cell epitopes and the investigation of the preferences of the different MHC alleles for particular motifs in cognate peptide sequences. The combination of these different strategies opens new possibilities for basic, as well as for applied, immunology. The outlines of the strategies for determination of natural T-cell epitopes are well established. These strategies have contributed substantially to our understanding of the nature of T-cell epitopes and of many diseases. Positional scanning approaches with random synthetic peptide libraries allow comprehensive surveys of the sequence requirements for peptide selection by MHC molecules and for induction of T-cell responses. Synthetic T-cell epitopes can be determined independently of the knowledge of the natural T-cell antigen. This opens new perspectives for the development of synthetic vaccines, TCR antagonists and MHC blockers.
P Walden
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in immunology     Volume:  8     ISSN:  0952-7915     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-11-12     Completed Date:  1996-11-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  IM    
Dermatologische Klinik, Humboldt-Universität, Berlin, Germany.
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MeSH Terms
Antigen Presentation*
Epitopes / chemistry
Histocompatibility Antigens Class I / immunology
Histocompatibility Antigens Class II / immunology
Receptors, Antigen, T-Cell / chemistry*
T-Lymphocytes / chemistry*,  immunology
Reg. No./Substance:
0/Epitopes; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II; 0/Receptors, Antigen, T-Cell

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